Publication - Abstract
Aug 11, 2021
Advanced Science
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Publication - Abstract
Aug 11, 2021
Advanced Science
Publication - Abstract
Apr 08, 2021
Nanomaterials
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Mar 15, 2021
Acta Biomaterilia
Publication - Abstract
Jan 08, 2021
Scientific Reports
Publication - Abstract
Dec 16, 2020
pharmaceutics
Publication - Abstract
Dec 16, 2020
Advanced Therapeutics
Publication - Abstract
Dec 10, 2020
Journal of Orthopaedic Research
Publication - Abstract
Aug 30, 2020
International Journal of Pharmaceutics
Publication - Abstract
Jun 11, 2020
Pharmaceuticals
Publication - Abstract
May 02, 2020
Processes
Publication - Abstract
Mar 13, 2020
Pharmaceutics
Publication - Abstract
Feb 26, 2020
International Journal of Molecular Sciences
Publication - Abstract
Feb 24, 2020
Pharmaceutical Research
Publication - Abstract
Feb 20, 2020
Nanotechnology
Publication - Abstract
Dec 09, 2019
International Journal of Molecular Sciences
Publication - Abstract
Dec 04, 2019
Pharmaceutics
Publication - Abstract
Sep 22, 2019
International Journal of Molecular Sciences
Publication - Abstract
Sep 06, 2019
Small
Publication - Abstract
Aug 05, 2019
Molecular Pharmaceutics
Publication - Abstract
Mar 13, 2019
Nanomedicine: Nanotechnology, Biology and Medicine
Publication - Abstract
Feb 27, 2019
Cell Chemical Biology
Brent Stockwell’s lab at Columbia University demonstrated the efficacy of a small molecule encapsulated in a PEG-PLGA nanoparticle for inducing a form of cell death called ferroptosis (discovered by the Stockwell Lab) in diffuse large B cell lymphoma (DLBCL) mouse models...
Publication - Abstract
Feb 15, 2019
International Journal of Nanomedicine
Publication - Summary
Feb 07, 2019
Nano Research
Publication - Abstract
Jan 29, 2019
Pharmaceutics
Publication - Summary
Jan 14, 2019
Cancer Immunology, Immunotherapy
Publication - Abstract
Dec 09, 2018
Pharmaceutics
Publication - Abstract
Nov 12, 2018
Biomaterials Science
Publication - Abstract
Oct 10, 2018
Drug Delivery and Translational Research
Publication - Abstract
Oct 08, 2018
Nature Medicine
Publication - Abstract
Sep 05, 2018
Nanotheranostics
Publication - Abstract
Jul 04, 2018
Nature communications
Publication - Abstract
Jun 01, 2018
Biological and Pharmaceutical Bulletin
Publication - Abstract
May 25, 2018
Multiple Myeloma
Publication - Abstract
May 07, 2018
Bioconjugate Chemistry
Publication - Abstract
Apr 26, 2018
Small Methods
Lipid nanoparticles (LNPs) are currently the most clinically advanced nonviral carriers for the delivery of small interfering RNA (siRNA). Free siRNA molecules suffer from unfavorable physicochemical characteristics and rapid clearance mechanisms, ...
Publication - Abstract
Apr 16, 2018
Acta Biomaterialia
Macrophage hyperfunction or dysfunction is tightly associated with various diseases, such as osteoporosis, inflammatory disorder, and cancers. However, nearly all conventional drug delivery system (DDS) nanocarriers utilize endocytosis for ent...
Publication - Abstract
Apr 12, 2018
Biomaterials Science
Publication - Abstract
Apr 05, 2018
Advanced Drug Delivery Reviews
Nanopharmaceuticals aim at translating the unique features of nano-scale materials into therapeutic products and consequently their development relies critically on the progression in manufacturing technology to allow scalable processes complying w...
Publication - Abstract
Mar 19, 2018
Advanced Drug Delivery Reviews
Lipid-based nanobiomaterials as liposomes and lipid nanoparticles (LNPs) are the most widely used nanocarriers for drug delivery systems (DDSs). Extracellular vesicles (EVs) and exosomes are also expected to be applied as DDS nanocarriers. The perf...
Publication - Abstract
Feb 12, 2018
Journal of Nanobiotechnology
The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to batch variability. Additionally, the p...
Publication - Summary
Nov 24, 2017
International Journal of Pharmaceutics
Polymeric nanoparticles are efficient drug delivery vehicles that can deliver a wide range of bioactive agents. Specifically, poly(lactic-co-glycolic acid) copolymer (PLGA) based nanoparticles are biocompatible and biodegradable and approved by the...
Publication - Summary
Sep 01, 2017
Scientific Reports
Currently, clinically approved medicines with liposomal formulations have a combined annual revenue of approximately $100 million USD, but their difficult and expensive production methods make more widespread use prohibitive. Microfluidic devi...
Publication - Abstract
Aug 29, 2017
Journal of Liposome Research
Understanding the effect of liposome size on tendency for accumulation in tumor tissue requires preparation of defined populations of different sized particles. However, controlling the size distributions without changing the lipid composition is d...
Publication - Abstract
May 27, 2017
Journal of Pharmaceutical Sciences
Lipid-polymer hybrid nanoparticles (NPs) are advantageous for drug delivery. However, their intracellular trafficking mechanism and relevance for oral drug absorption are poorly understood. In this study, self-assembled core-shell lipid-polymer hyb...
Publication - Summary
May 11, 2017
Biomaterials
Metastatic and multidrug resistant (MDR) tumors are generally very challenging to treat; and while in many cancers early detection can increase the survival rate significantly, the mortality rates of advanced and metastasized cancers are still quit...
Publication - Abstract
Jan 10, 2017
International Journal of Pharmaceutics
Publication - Abstract
Nov 21, 2016
The AAPS Journal
Cytotoxic chemotherapeutic agents are used as the standard therapy for a range of significant cancers, but many of these drugs suffer from poor water solubility and low selectivity, limiting their clinical efficacy. To overcome these shortcomings, ...
Publication - Summary
Nov 15, 2016
International Journal of Pharmaceutics
Liposomes are lipid-based supramolecular assemblies that can be engineered into efficacious drug carriers. Typically described as bilayer systems with an aqueous core, liposomes can increase the therapeutic index of a given drug molecule by decreas...
Publication - Abstract
Sep 13, 2016
Chemical Society Reviews
Molecular self-assembly has enabled the fabrication of biologically inspired, advanced nanostructures as lipid-based nanovesicles (L-NVs). The oldest L-NVs, liposomes, have been widely proposed as potential candidates for drug delivery, diagnostic ...
Publication - Abstract
Aug 05, 2016
Journal of Drug Targeting
Microfluidic devices are mircoscale fluidic circuits used to manipulate liquids at the nanoliter scale. The ability to control the mixing of fluids and the continuous nature of the process make it apt for solvent/antisolvent precipitation of drug-d...
Publication - Abstract
Oct 14, 2015
Chemical Reviews
Described first in the 1960s by Bangham1 and understood as a potential drug delivery system in the early 1970s,2−4 the liposome has since become integral to research and clinical applications in the field of nanomedicine.
Publication - Summary
Jun 03, 2015
Biomaterials
Many chemotherapeutic anticancer agents target vital components of cell division and inhibit survival and growth of cancer cells. Anti-tubulin agents for example, target the microtubule complex formed during mitosis and result in cell apoptosis. Read More
Publication - Abstract
May 15, 2015
International Journal of Pharmaceutics
Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is ...
Publication - Summary
Aug 25, 2014
International Journal of Pharmaceutics
Metastatic castration-resistant prostate cancer (mCRPC) is an advanced form of prostate cancer with poor prognosis and very few treatment options. Fractures and bone pain due to loss of bone density caused by bone metastasis is highly prevalent, re...
Publication - Summary
Feb 21, 2012
Langmuir
The potency of drug delivery systems can heavily rely on their ability to penetrate poorly vascularized tissues such as tumors, following intravenous administration. The drug delivery vehicle’s size greatly impacts this phenomenon.
Application Note
Mar 02, 2017
Application Note
Mar 01, 2017
Application Note
Mar 01, 2017
Application Note
Jul 01, 2017
Application Note
Jul 01, 2018
Video
Aug 04, 2017
Dr. Shyam Garg, Formulation Scientist II, Precision NanoSystems Inc. - 2nd Annual Nanomedicines Symposium
Video
Aug 10, 2016
NanoAssemblr® Benchtop Tech Talk from 2016 Nanomedicine Symposium
Video
Jul 26, 2016
Liposomes: from Prototype to the Clinic | Norbert Maurer, Transferra Nanosciences
Video
Dec 15, 2016
Keynote Speaker from our Nanomedicines Symposium November 29th, London UK
Ray Schiffelers - Facing the Challenge of Reproducible and Scalable Nanoparticle Production for RNA Delivery - Keynote
Video
Nov 20, 2016
Nanomedicines Symposium, November 29th, 2016 - London UK
Dimitrios Lamprou - Lipid Formulations: Microfluidics vs Traditional Method - Kent University
Webinar
Aug 04, 2017
Webinar
Jun 29, 2017
Dr. Shyam Garg, Formulation Scientist II at Precision NanoSystems Inc.
Webinar
Jun 21, 2016
Microfluidic-mediated self-assembly of liposomes and polymer nanoparticles expands the strategies available to the formulation scientist for the encapsulation and delivery of hydrophobic compounds. In this webinar Dr. James Taylor and Dr. Shyam Gar...
Webinar
Jun 17, 2016
Dr. Shyh-Dar Li from the University of British Columbia introduced the design, synthesis and fabrication of a self-assembled polymeric nanoparticle system, and the use of which to deliver insoluble anticancer drugs for therapy of tumors in preclini...
Webinar
Apr 26, 2016
In this webinar, Professor Pieter Cullis from the University of British Columbia will unpack the application of microfluidics for the preparation of "limit-size" lipid nanoparticle systems including liposomes, nanoemulsions and RNA-lipid nanopartic...