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Jul 28, 2022
RNA vaccines are hugely versatile. They can potentially inoculate against any pathogen for which a protein target is known, for example, influenza, chlamydia, HIV-1 (human immunodeficiency virus 1), Ebola and RSV (respiratory syncytial virus). Self-amplifying RNA (saRNA) is a typ... -
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Mar 01, 2022
Precision NanoSystems maintains that mRNA and LNP technologies, microfluidics, and distributed manufacturing will revamp vaccine production.
LATEST ARTICLES
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Jan 18, 2023
Lipid Nanoparticles (LNPs) are nanoparticles formed by lipid components that are one of the effective means for mRNA delivery. Although the emergence of variants of COVID-19 has encouraged greater demands for developing mRNA–LNP vaccines, its benefits extend beyond vaccinations t... -
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Dec 07, 2022
Limit size behavior, in-line dilution and tangential flow filtration are important process considerations to evaluate and optimize during process development. -
Article
Sep 28, 2022
Nanomedicine offers promising therapeutic solutions for cell and gene therapies, autoimmune diseases, oncology, rare inherited diseases and more. Some new avenues to explore include early disease detection or molecularly tailored treatments for patients who have complex diseases ... -
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Sep 28, 2022
The production of RNA lipid nanoparticles (LNPs) such as those used in COVID-19 vaccines involves mixing RNA in an aqueous buffer with lipids dissolved in ethanol to trigger the self-assembly of LNPs. The mixing conditions of the RNA and lipids are crucial to drug product quality... -
Article
Sep 20, 2022
COVID vaccine development has proven that genomic medicines have the potential for faster drug development. Along with potential therapies across screening, prevention, and treatment options, genomic medicines can target the disease-causing gene mutations, offering a more accurat... -
Article
Jun 09, 2022
Scale-up and downstream processing operations can impact the functionality and stability of mRNA-LNPs in vaccine development including COVID-19 vaccines. -
Article
Mar 01, 2022
During development of pharmaceutically-applicable mRNA therapeutics, synthesis, optimization, and formulation must be taken into consideration.
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