DiseaseAoIheader

 

Lipid Nanoparticle

Portfolio

Our lipid nanoparticle (LNP) portfolio provides access to off-the-shelf kits and custom formulations for developing nucleic acid therapeutics that seamlessly transition from discovery to the clinic. Rationally design LNP formulations to validate active pharmaceutical ingredients (APIs), generating proof-of-concept and efficacy data that allows progression of lead candidates quickly through screening and in vitro preclinical studies to accelerate in vivo clinical development.

 

In addition to liposomes and polymeric nanoparticles (poly(lactic-co-glycolic acid) PLGA) nanomedicines, LNP delivery technology is clinically proven with mRNA delivery for gene therapy through Onpattro, COVID-19 vaccines and is currently in clinical trials for several cell therapy applications including CRISPR-Cas9 gene editing, protein replacement therapy and more. Precision NanoSystems offers an easily accessible and well characterized lipid nanoparticle portfolio and nanomedicine formulation technologies for these applications and future RNA-based therapeutics.  

 

 

Get in Touch with a Specialist
Fit-For-Purpose Lipid Nanoparticle Portfolio
Lipid Nanoparticle Portfolio LNP Diagram

 

In genomic medicines, the drug delivery challenge is getting the active pharmaceutical ingredient (API) into the target cells at the disease site. Lipid nanoparticles (LNPs) are an elegant solution for DNA or RNA delivery as they protect the cargo from degradation and mediate a safe and targeted intracellular delivery.

Lipid nanoparticles consist of ionizable cationic lipids, helper lipids, cholesterol, and stabilizers, each having a specific role in delivery of the genomic medicine to its site to activation. Due to their modular nature, excipients can be mixed, matched, and modified during LNP formulation to target different organs in the body and improve the encapsulated drug's efficacy and pharmacokinetic profile. 

In particular, ionizable lipids offer a unique capability to shift charge with pH changes to ensure strong binding of nucleic acids during LNP formulation while maintaining a neutral charge under physiological pH to limit cytotoxic effects. They are the main component that enable efficient cellular delivery and overcome payload size limitations. Access to a lipid nanoparticle portfolio with an array of ionizable cationic lipids allows for LNP optimization for targeted nanomedicines.  

 

Read more about research focused on individual excipients and their role in  RNA delivery and LNP delivery strategies to discover how lipid nanoparticles properties can affect function.

 

 

Discover more about Lipid Nanoparticles

 

 

Alterations in the chemical structure and ratio of the LNP components affect its delivery efficiency, potency, and biodistribution, making it essential to optimize lipid nanoparticles for each application so that it is Fit-For-Purpose. LNP formulations are not one-size-fits-all, as ionizable cationic lipids that are effective for mRNA vaccines may not be well-suited for gene editing or cell therapies.  

Aside from safety and potency, optimizing ionizable lipids for structural properties, targeted RNA delivery and immunomodulation can be labour-intensive. Access to a lipid nanoparticle portfolio that includes systematic categorization of these lipids allows for rationally designed custom LNP formulations that help developers quickly reach the full potential of nucleic acid therapeutics across applications.

 

 

Learn about Optimizing Lipid Nanoparticles

Accelerate Preclinical and Clinical Drug Development

 

 

Our end-to-end Genomic Medicine Tool Kit uniquely enables access to ionizable lipid mixes through the lipid nanoparticle portfolio, LNP technologies and proven expertise, to establish robust in-house strategies and infrastructure. This results in a sustainable LNP formulation and manufacturing framework that accelerates drug candidates across indications from discovery to the clinic. 

 

 

  • Lipid Nanoparticle Portfolio Disease Target
    Disease Target
    Identify gene(s) driving disease and target delivery characteristics to create a profile for LNP delivery technology. 
Genomic Medicine Toolkit
  • Lipid Nanoparticle Portfolio Genetic Payload Platform
    Genomic Payload Platform
    DNA or RNA (including Self-amplifying mRNA) platform to express specific proteins, silence, or edit target gene(s).
  • Lipid Nanoparticle Portfolio GenVoy Platform
    GenVoy-ILM™ Delivery Platform
    Lipid nanoparticle portfolio that protects and delivers nucleic acids to target cells​, validating payloads in preclinical stages with seamless translation to the clinic.
  • Lipid Nanoparticle Portfolio Manufacturing Platform
    NanoAssemblr® Manufacturing Platform
    Microfluidic mixing technology for precise and reproducible LNP formulation, maintaining LNP characteristics through scale-up to GMP manufacturing. 
  • Lipid Nanoparticle PortfolioDrug Development Expertise
    Drug Development Expertise
    Leverage world-leading expertise for ionizable lipid selection and LNP formulation to optimize and accelerate genomic medicine development. 

 

 

Nucleic acid therapeutics including mRNA-LNP vaccines, gene therapy, cell therapy and more, demand different characteristics and indications from lipid nanoparticles, requiring fit-for-purpose optimization to produce effective nanomedicines. To accelerate development, the lipid nanoparticle portfolio offers off-the-shelf LNP formulations designed for specific applications with a clear path to the clinic, and proven expertise in biopharma services to help in selecting appropriate ionizable cationic lipids for custom applications.   

These easy-to-use kits or custom formulations enable any researcher to become a genomic medicine developer as they offer ionizable lipids for broad or targeted applications. This saves significant time for validation of target payloads and lowers the risk of developing a bespoke lipid nanoparticle formulation, accelerating preclinical programs for lipid-based therapeutics. 

 

 

Lipid Nanoparticle Portfolio Acceleration

 

 

Accelerate Your LNP Therapeutics

Lipid Nanoparticle Portfolio Partnering
Trusted by experts

Partner with Precision NanoSystems to maximize the probability of commercial success through access to our lipid nanoparticle portfolio, nanomedicine technologies, and LNP formulation expertise to optimize and accelerate drug candidates across applications from discovery to the clinic.  

logo-replicate-blue


We are proud to join forces with Replicate Bioscience to leverage our lipid nanoparticle library to accelerate the creation, scale-up, and delivery of up to 15 self-replicating RNA (srRNA) therapies. Optimization of the ionizable lipids and LNP delivery technology will maximize the srRNA vector performance, enabling Replicate Bioscience to target new diseases and develop novel drug candidates. 

University of Alberta Logo

 

In collaboration with Nobel Laureate Sir Michael Houghton at Aurora Vaccines, a spin-off company from the University of Alberta, Precision Nanosystems shares its expertise and lipid nanoparticle portfolio to help bring Aurora's RNA-LNP vaccine candidate for the prevention of Hepatitis C virus (HCV) infection to a Phase I clinical trial.  

 

We are engaged with 90% of established mRNA delivery genomic developers and look to establish strategic partnerships to enable and accelerate development of nanomedicines from discovery to commercial scale manufacturing. Our team has expertise ranging from collaborations for small-scale rare disease applications with unmet therapeutic needs to robust clinical applications with global implications.    

 

logo-replicate-blue
Lipid Nanoparticle Portfolio Access

Access ready-to-use ionizable lipid mixes or custom LNP formulations to progress lead candidates quickly through preclinical stages and license those same formulations in clinical development, accelerating transitions from discovery to the clinic. 

 

 

Lipid Nanoparticle Portfolio Clinical LNP Library
GenVoy-ILM™ Reagent Kits

 

Off-the-shelf lipid nanoparticle reagent kits for broad and targeted applications, leveraging Precision NanoSystems’ LNP formulation expertise, to quickly validate and progress lead candidates through preclinical drug development. For research use only. 

GenVoy-ILM™ Lipid Nanoparticle Formulations

 

Portfolio includes lipid excipients and lipid nanoparticle formulations that can be optimized and licensed through clinical stages to commercialization, helping establish targeted and scalable drug candidates quickly across applications. 

 

 

 

Lipid Nanoparticle Portfolio Accessible

 

Accessible

 

Ready-to-use kits with lipid mixes for optimized applications. Quickly and easily validate drug candidates without being a LNP formulation expert. 

Lipid Nanoparticle Portfolio Clear Path to Clinic

 

Clear Path to Clinic

 

Accelerate drug development using ionizable lipid mixes that can validate preclinical candidates and be licensed for clinical trials and commercial manufacturing. 

Lipid Nanoparticle Portfolio Reliable

 

Reliable

 

Robust supply chain for ionizable cationic lipids and other excipients, with proven stability and long shelf-life for consistent lipid nanoparticle formulations.

Lipid Nanoparticle Portfolio High Quality

 

High Quality

 

Excellent purity and well documented characterization of lipids and components, ensuring homogenous and reproducible LNP formulations batch-to-batch. 


GMP lipids available for GMP processes. 
 

Lipid Nanoparticle Portfolio Trusted Expertise

 

Trusted Expertise

 

Leverage our trusted and proven team for ionizable lipid selection and to customize fit-for-purpose lipid compositions, building our expertise into your drug product.

Lipid Nanoparticle Portfolio Enabled Applications

Nanomedicines represent the next paradigm in drug innovation with lipid-based nanoparticles offering revolutionary new treatment modalities including saRNA and mRNA-LNP vaccines, gene therapy and cell therapy based on LNP delivery technology.

 

 

Lipid Nanoparticle Portfolio Vaccine Icon Lipid Nanoparticle Portfolio Vaccine Application

 

  • Capable of mRNA and saRNA infectious disease vaccine applications 
  • High potency In Vitro  
  • Protected rodent subjects from weight loss and increase in lung weight following viral challenge  
  • Reduction of viral loads in nasal wash and respiratory tissues following viral challenge  
  • Maintained biological performance during scale up, such as high IgG levels in mice, hamsters, and NHPs 

 

 

Lipid Nanoparticle Portfolio Gene Therapy Icon Lipid Nanoparticle Portfolio Protein Replacement Application

 

  • Capable of protein replacement and hepatic delivery applications
  • Confirmed hepatic targeted delivery
  • Produced significant protein expression levels following administration
  • Confirmed therapeutic effect through measurable increase in downstream biological activity
  • Performed equivalently or better than clinically approved lipids

     

     

Lipid Nanoparticle Portfolio Cell Therapy Icon Lipid Nanoparticle Portfolio Protein Replacement Application

 

  • Capable of multiplex gene editing and delivery applications 
  • Highly viable cells, even after sequential genetic manipulation 
  • Highly efficient at both gene knockouts and protein expression 
  • Validated with downstream cell manufacturing workflow 
  • Maintained biological performance during scale up 

 

 

Get Started

Partner with Precision NanoSystems to access our lipid nanoparticle portfolio and optimize fit-for-purpose LNP formulations to establish and accelerate clinically relevant, scalable drug candidates that easily transition to full-scale commercial manufacturing.

Partner with PNI
Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.