The

NanoAssemblr®

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Power to Advance

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Accessories & Reagents

Advance Novel Genetic Medicine Formulations

Genetic medicines have a wide design space that requires optimization to select a lead candidate. The Ignite is ideal for fine tuning process parameters and compositions for further scale up to the clinic.

Outstanding Reproducibility

Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.

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Scalable Technology

NxGen technology allows formulations to be rapidly scaled across the NanoAssemblr platform from 100 µL to 50 L.

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Simple Workflow

Easy setup with touchscreen interface, saved recipes and a single-use fluid path enables a streamlined workflow.

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Rapid Production

Over 50 formulations can be completed in a day for rapid optimization with each run taking less than one minute.

Versatile

Lipid, polymer or hybrid nanoparticles carrying small molecules, peptides or nucleic acids (and more) can be formulated on the Ignite.

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Controlled Assembly

Particle sizes can be tuned with precise control over fluid flow rates.

Ignite Empowers Genetic Medicine Advancement

NanoMedU

Learn more about Early Pre-clinical Development Level 1: RNA Vaccines. A focused virtual classroom and hands-on training to kick-start RNA-LNP vaccine development

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Quick and Easy to Use

The Ignite is simple to use and can be operated with little to no training. Formulations can be completed in under a minute and made on demand to quickly optimize experimental parameters.

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Ignite Process Illustrations-01

Insert Cartridge

Load Pre-filled Syringes

Choose a Recipe

Load Collection Tubes

Start Formulation

Collect Sample

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact a Scientific Specialists.

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Scale Formulations with NxGen Technology Across the NanoAssemblr Platform

Using the same microfluidic geometry, formulations are scalable across the NanoAssemblr® platform greatly reducing process and formulation redevelopment when changing scales. Lipid nanoparticles containing nucleic acids maintain identical size and PDI when scaled across the platform.

Particle Size, polydispersity and hematocrit expression were consistent as production of mRNA-LNP was scaled using the NanoAssemblr platform.

Optimize Genetic Medicine Formulations

Rationally optimize your formulations by controlling process and chemical parameters like flow rate, concentration and charge. Quick formulation times allow for an efficient systematic approach to finding lead genetic medicine candidates.

Starting concentration, total flow rate and flow rate ratio parameters were varied, and 5 replicates were performed for each data point.

Enable Preclinical Experiments with Reproducible Formulations

Reproducibility across batches and users to enable critical preclinical experiments needed like small animal studies for genetic medicine development.

Particle size and encapsulation efficiency were performed in 4 replicates. Protein expression (Epo) experiments performed to show in vivo efficacy of mRNA-LNP.

Advanced Technology for Advanced Nanomedicines

NxGen technology provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.

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An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge

Under laminar flow, the two phases do not immediately mix

Microscopic features engineered into the channel reproducibly control the mixing of the two streams

Rapid, controlled, homogenous mixing produces homogeneous nanoparticles

Videos and Demonstrations

Ignite Demo with GenVoy Training Kit

Ignite Informational Presentation

GenVoy Ignite Demo

Accessories and Reagents

The Ignite has accessories and reagents available to expand the formulation capabilities and empower users to advance their genetic medicine.

Heating Package

The heating package empowers users to heat and keep their formulations in syringes at temperature when operating the Ignite.

GenVoy-ILM

GenVoy-ILM is an off-the-shelf, research use only reagent that lowers the barriers the genetic medicine development that can be used on the Ignite.

Cartridges

NanoAssemblr Ignite cartridges feature exclusive NxGen microfluidic technology that allows future scale up through a single mixer from ml/min to L/h.

Single Use Cartridges

No priming or cleaning required for an efficient workflow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations.

Automatic Inline Dilution

Automated in-line dilution allows modelling of the processes that will be required for future GMP production of nanoparticles.

Brochure

The NanoAssemblr® Ignite™ system is designed with the end in mind, designed for the future and designed to maximize time.

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Resource Center

Publication - Abstract

September 15, 2021

Vaccine

N. Arizmendi, H. Qian, Y. Li and M. Kulka

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