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Power to Advance

NanoAssemblr Ignite
Polymeric Nanoparticle & Liposome
Ignite: Advancing Transformative Medicines
The Ignite with NxGen Technology embodies everything that makes the NanoAssemblr Platform the go-to for genetic medicine development for over 100 biopharma companies, while bringing the latest innovations developed for the cGMP system to the bench — saving time and money.
Designed with the End in Mind

Designed with End in Mind

Enabling researchers to create genetic medicines at the bench scale

Designed for the Future

Designed for Future

Enabling the creation of transformative medicines yet to be imagined

Designed to Maximize Time

Designed to Maximize Time

Enabling the creation of genetic medicines by accelerating data generation

Ignite Empowers Genetic Medicine Advancement

Designed with the End in Mind.
Providing the capabilities to develop a robust, scalable process from the earliest stage
The manufacturing process on the GMP system can be modelled at any stage across the NanoAssemblr Platform with NxGen Technology. Ignite enables clinically relevant development processes at the bench.

DWEM - Unit Operation Workflow


Reduce the risk during transition from Research into Development


Reduce cost since downstream equipment is available at CMO facilities


Accelerate timelines to Investigational New Drug Applications

Designed for the Future
As a team of scientists, engineers, and much more, we are working together to advance the technologies that lead the way in genetic medicine
NxGen microfluidics plus the third-inlet capability of the Ignite instrument provides an expandable system where new cartridge designs enable new applications.

Ignite Dilution Cartridge

The NanoAssemblr Ignite NxGen Dilution Cartridge enables automated in-line dilution of the nanoparticles as they emerge from the microfluidic mixer.

Designed to Maximize Time
Time should be prioritized designing and executing experiments, and analyzing data
Manufacturing processes should not be long and complex or increase risk of process error, batch failure, poor quality particles or unreliable data. Process development should not be limited to experienced specialists.

Intuitive software allows frequently used manufacturing recipes to be stored minimizing batch-to-batch and user variability.



System is ready in 3 simple steps with no priming or cleaning required. Genetic medicine formulations can be prepared in minutes allowing rapid optimization of particle properties.


Polymeric Nanoparticle & Liposome
Summary of Features

NxGen logo

The Ignite brings the highly scalable power of NxGen microfluidic technology to the bench. The NxGen mixer uses precisely controlled time-invariant mixing to reproducibly generate optimal particles through a single mixer across scales. 


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outstanding reproducibility

Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.

intuitive workflow

Easy setup with touch screen interface, saved recipes and a single-use fluid path that eliminates priming and cleaning enables a streamlined workflow.

controlled assembly

Tune particle size with precise control over fluid flow rates.


Formulate small molecules, peptides and, nucleic acids into lipid, polymer or hybrid nanoparticles, and more.


speedy and efficient

Formulation runs require less than a minute. Over 50 formulations can be completed in a day for rapid optimization.



Easily scale between 1mL and 20mL formulations on the Ignite. Optimized formulations can be predictably scaled to advanced preclinical and clinical scale with Blaze™ and GMP Systems with NxGen technology.

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Advanced Technology for
Advanced Nanomedicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.


An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge


Under laminar flow, the two phases do not immediately mix


Microscopic features engineered into the channel reproducibly control the mixing of the two streams


Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
NanoAssemblr Technology
Ignite Video


Ignite Demo with GenVoy Training Kit


Ignite Informational Presentation


GenVoy Ignite Demo

Ignite Cartridges

NanoAssemblr Ignite cartridges feature exclusive NxGen microfluidic technology that preserves time-invariant particle formation conditions and allows future scale up through a single mixer from ml/min to L/h.


Ignite cartridges are single use. No priming or cleaning required for an efficient workflow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations. 






Ignite Dilution Cartridge

Ignite cartridges with NxGen Technology are also available with automated in-line dilution of the nanoparticles to allow modelling of the processes that will be required for future GMP production.

Ignite Brochure
Ignite BrochureThe NanoAssemblr® Ignite™ system is designed with the end in mind, designed for the future and designed to maxmize time.

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Resource Center

Publication - Abstract

December 16, 2020


Applying Microfluidics for the Production of the Cationic Liposome-Based Vaccine Adjuvant CAF09b

S.T. Schmidt, D. Christensen and Y. Perrie

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Publication - Abstract

December 16, 2020

Advanced Therapeutics

Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating In Vitro and In Vivo Encaps...

C.B. Rodell, P. Baldwin, B. Fernandez, R. Weissleder, S. Sridhar and J.M. Dubach

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Publication - Abstract

November 30, 2020

International Journal of Pharmaceutics

Microfluidic Production of Protein Loaded Chimeric Stealth Liposomes

M.T. Hussain, M. Tiboni, Y. Perrie and L. Casettari

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Publication - Abstract

November 19, 2020

Molecular Pharmaceutics

Recent Advances in Microfluidics for the Preparation of Drug and Gene Delivery Systems

M.A. Tomeh and X. Zhao

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Publication - Abstract

November 18, 2020

Science Advances

Engineered Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fi...

A. Mukherjee, K.D. MacDonald, J. Kim, M.I. Henderson, Y. Eygeris and G. Sahay

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Publication - Abstract

November 15, 2020


Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

C.B. Roces, G. Lou, N. Jain, S. Abraham, A. Thomas, G.W. Halbert and Y. Perrie

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