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GenVoy-ILM™

Power to Explore

 

GenVoy-ILM, an off-the-shelf Research Use Only lipid nanoparticle reagent, lowers the barriers to developing genetic medicines


Explore Genetic Medicine with GenVoy-ILM

 

 

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The RNA chemistry, the lipid composition and the manufacturing process affect characteristics of the resultant lipid nanoparticle.

 

 

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GenVoy-ILM Demonstration on the NanoAssemblr® Ignite

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Overview

GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

 

 

An exclusive ionizable cationic lipid mix for preclinical development

 

With applications in Genetic Vaccine, Gene Therapy and Cell Therapy

 

For the treatment of cancer, rare disease, and infectious disease.

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

 

Endogenous Uptake

 

Deliver mRNA for Gene Expression

 

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A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.

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Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

 

 

Learn More About Lipid Nanoparticles


Nucleic Acid Lipid Nanoparticle

 

Both The Chemistry And The Process Determine The Outcome

 

LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



Use Genvoy-ILM for: 

 

Gene silencing Gene editing 
Gene expression Gene modulation 



Use GenVoy-ILM to encapsulate and deliver: 

 

siRNAgRNA
miRNAmRNA
saRNA 
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Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

2 mL, 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 

 

 


Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Resource Center

Publication - Abstract

March 19, 2018

Advanced Drug Delivery Reviews

Advances in Microfluidics for Lipid Nanoparticles and Extracellular Vesicles and Applications in Drug Delivery...

M. Maekia, N. Kimurab, Y. Satoc, H. Harashimac and M. Tokeshi

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Video

August 16, 2017

Lipid Nanoparticles to Deliver Nucleic Acids in Neuroscience Research - Peter Johnson, PNI

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Publication - Abstract

March 10, 2020

ACS Chemical Biology

Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs

Q. Li, C. Chan, N. Peterson, R.N. Hanna, A. Alfaro, K.L. Allen, H. Wu, W.F. Dall'Acqua, M....

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Publication - Abstract

January 01, 2015

Journal of Nanomedicine and Nanotechnology

The Potential Use of Nanoparticles for Noggin siRNA Delivery to Accelerate Bone Formation in Distraction Osteo...

A.C.F. Bassit, P. Moffatt, M.H. Gaumond and R. Hamdy

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Publication - Abstract

July 16, 2016

Molecular Therapy Nucleic Acids

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Scle...

G. Basha, M. Ordobadi, W.R. Scott, A. Cottle, Y. Liu, H. Wang and P.R. Cullis

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Publication - Abstract

January 08, 2018

Scientific Reports

High Content Image Analysis Reveals Function of miR-124 Upstream of Vimentin in Regulating Motor Neuron Mitoch...

T. Yardeni, R. Fine, Y. Joshi, T. Gradus-Pery, N. Kozer, I. Reichenstein, E. Yanowski, S. ...

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