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GenVoy-ILM™

Power to Explore

 

GenVoy-ILM, an off-the-shelf Research Use Only lipid nanoparticle reagent, lowers the barriers to developing genetic medicines


Explore Genetic Medicine with GenVoy-ILM

 

 

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The RNA chemistry, the lipid composition and the manufacturing process affect characteristics of the resultant lipid nanoparticle.

 

 

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GenVoy-ILM Demonstration on the NanoAssemblr® Ignite

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Overview

GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

 

 

An exclusive ionizable cationic lipid mix for preclinical development

 

With applications in Genetic Vaccine, Gene Therapy and Cell Therapy

 

For the treatment of cancer, rare disease, and infectious disease.

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

 

Endogenous Uptake

 

Deliver mRNA for Gene Expression

 

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A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.

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Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

 

 

Learn More About Lipid Nanoparticles


Nucleic Acid Lipid Nanoparticle

 

Both The Chemistry And The Process Determine The Outcome

 

LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



Use Genvoy-ILM for: 

 

Gene silencing Gene editing 
Gene expression Gene modulation 



Use GenVoy-ILM to encapsulate and deliver: 

 

siRNAgRNA
miRNAmRNA
saRNA 
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Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

2 mL, 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 

 

 


Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Resource Center

Publication - Abstract

March 23, 2021

ACS Nano

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanopartic...

F. Sebastiani, M.Y. Arteta, M. Lerche, L. Porcar, M. Cárdenas, et. al.

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Video

July 26, 2016

Liposomes: from Prototype to the Clinic | Norbert Maurer, Transferra Nanosciences

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Publication - Abstract

March 01, 2014

Endocrinology

IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in M...

U.H. Neumann, S. Chen, Y.Y. Tam, R.K. Baker, S.D. Covey SD, P.R. Cullis and T.J. Kieffer

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Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

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Publication - Summary

December 16, 2016

Angewandte Chemie International Edition

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 m...

Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ

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Publication - Abstract

November 13, 2017

Frontiers in Immunology

Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemaggluti...

G. Lindgren, S. Ols, F. Liang, E.A. Thompson, A. Lin, F. Hellgren, K. Bahl, S. John, O. Yu...

Read More 阅读更多
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