Power to Explore


GenVoy-ILM, an off-the-shelf Research Use Only lipid nanoparticle reagent, lowers the barriers to developing genetic medicines

Explore Genetic Medicine with GenVoy-ILM



Screen Shot 2020-04-29 at 12.22.09 AM

The RNA chemistry, the lipid composition and the manufacturing process affect characteristics of the resultant lipid nanoparticle.



Download the Brochure

GenVoy-ILM Demonstration on the NanoAssemblr® Ignite

Screen Shot 2020-04-29 at 12.11.19 AM

GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.



An exclusive ionizable cationic lipid mix for preclinical development


With applications in Genetic Vaccine, Gene Therapy and Cell Therapy


For the treatment of cancer, rare disease, and infectious disease.

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.


Endogenous Uptake


Deliver mRNA for Gene Expression


Screen Shot 2019-06-21 at 2.58.04 PM

A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.

Screen Shot 2020-04-29 at 12.39.25 AM
Screen Shot 2020-04-29 at 12.39.40 AM
Screen Shot 2020-04-29 at 12.40.06 AM
Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.


At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.


These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.



Learn More About Lipid Nanoparticles

Nucleic Acid Lipid Nanoparticle


Both The Chemistry And The Process Determine The Outcome


LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 

Use Genvoy-ILM for: 


Gene silencing Gene editing 
Gene expression Gene modulation 

Use GenVoy-ILM to encapsulate and deliver: 


Screen Shot 2020-04-29 at 12.11.38 AM
Screen Shot 2020-04-29 at 12.12.10 AM

Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.


2 mL, 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 



Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

Resource Center

Publication - Summary

April 27, 2017

Molecular Therapy

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines Against H10N8 and H7N9 Influenza Vir...

K. Bahl, J.J. Senn, O. Yuzhakov, A. Bulychev, L.A. Brito, K.J. Hassett, M.E. Laska, M. Smi...

Read More 阅读更多

Publication - Abstract

November 26, 2020

Journal of Controlled Release

Effect of Complexing Lipids on Cellular Uptake and Expression of Messenger RNA in Human Skin Explants

A.K.. Blakney, P. Deletic, P.F. McKay, C.R. Bouton, M. Ashford, R.J. Shattock and A. Sabir...

Read More 阅读更多


November 08, 2017

Nano-sized Delivery Systems for Vaccines—Precision NanoSystems Webinar 2017

Read More 阅读更多

Publication - Abstract

March 01, 2014


IGFBP2 Is Neither Sufficient nor Necessary for the Physiological Actions of Leptin on Glucose Homeostasis in M...

U.H. Neumann, S. Chen, Y.Y. Tam, R.K. Baker, S.D. Covey SD, P.R. Cullis and T.J. Kieffer

Read More 阅读更多


July 26, 2016

Liposomes: from Prototype to the Clinic | Norbert Maurer, Transferra Nanosciences

Read More 阅读更多

Publication - Summary

February 07, 2019

Molecular Therapy Nucleic Acids

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

K.J Hassett, K.E. Benenato, E. Jacquinet, L.A. Brito, et al.

Read More 阅读更多
Resource Center 资源中心
Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.