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The
NanoAssemblr®
Benchtop
The NanoAssemblr® Benchtop has been discontinued. To advance transformative medicines, please see our NanoAssemblr® Ignite™.
NanoAssemblr Benchtop
Polymeric Nanoparticle & Liposome
Overcome key challenges
in nanomedicine development
with the Benchtop.
outstanding reproducibility

Computer control removes batch-to-batch and user variability.

intuitive workflow

Advanced microfluidics is simplified with easy connections and visual software.


controlled assembly

Tune particle size with precise control over fluid flow rates.

 
versatile

Formulate small molecules, peptides and, nucleic acids into lipid, polymer or hybrid nanoparticles, and more.

speedy and efficient

Formulation runs require less than a minute. 30 - 40 formulations can be completed in a day for rapid optimization.

 
scalable

Easily scale between 1mL and 15mL formulations on the Benchtop. Optimized formulations can be transferred to advanced preclinical and clinical scale with the Blaze™ and GMP Systems.

Easily optimize
nanoparticle size
Use simple software parameters such as Total Flow Rate (TFR) and Flow Rate Ratio (FRR) to fine tune particle size.
Optimize liposomal drug delivery systems Optimize Liposomal Drug Delivery
Develop polymeric drug delivery systems Develop Polymeric Drug Delivery
Robust,
reproducible
process
Minimizing process variability isolates the effects of materials, solvent choice, and concentrations on desired outcomes, enabling rational formulation design.
Batch-to-Batch Reproducibility from Independent UsersReproducibility: Independent Users

Isolate Effects of Formulation Parameters 

Isolate: Formulation Parameters

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

 

 

 

Advanced Technology for
Advanced Nanomedicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.

1

An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge

2

Under laminar flow, the two phases do not immediately mix

3

Microscopic features engineered into the channel reproducibly control the mixing of the two streams

4

Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
NanoAssemblr Technology
Videos

 

Overview

 

NanoAssemblr Technology

 

Benchtop Demo

Benchtop Cartridges
NanoAssemblr® Benchtop cartridges are semi-disposable and compatible with a wide range of solvents to make a diverse array of nanomedicine formulations.
NanoAssemblr Benchtop Cartridge
Benchtop Brochure
NanoAssemblr Benchtop BrochureThe NanoAssemblr® Benchtop system is designed for rapid prototyping of novel nanoparticle formulations of 1 to 15mL, that would be difficult to make with alternative manufacturing methods. The software enables the control of input mixing parameters for optimizing particle characteristics such as size and encapsulation efficiency.


Download Brochure

Resource Center

Publication - Abstract

December 16, 2020

pharmaceutics

Applying Microfluidics for the Production of the Cationic Liposome-Based Vaccine Adjuvant CAF09b

S.T. Schmidt, D. Christensen and Y. Perrie

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Publication - Abstract

December 16, 2020

Advanced Therapeutics

Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating In Vitro and In Vivo Encaps...

C.B. Rodell, P. Baldwin, B. Fernandez, R. Weissleder, S. Sridhar and J.M. Dubach

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Publication - Abstract

November 30, 2020

International Journal of Pharmaceutics

Microfluidic Production of Protein Loaded Chimeric Stealth Liposomes

M.T. Hussain, M. Tiboni, Y. Perrie and L. Casettari

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Publication - Abstract

November 19, 2020

Molecular Pharmaceutics

Recent Advances in Microfluidics for the Preparation of Drug and Gene Delivery Systems

M.A. Tomeh and X. Zhao

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Publication - Abstract

November 18, 2020

Science Advances

Engineered Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fi...

A. Mukherjee, K.D. MacDonald, J. Kim, M.I. Henderson, Y. Eygeris and G. Sahay

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Publication - Abstract

November 15, 2020

pharmaceutics

Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

C.B. Roces, G. Lou, N. Jain, S. Abraham, A. Thomas, G.W. Halbert and Y. Perrie

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Resource Center 资源中心