See How Spark Works for Yourself
The Spark demo will show you how the Spark can integrate into your workflow and accelerate your genetic medicine discovery.
Remarkably Fast and Easy to Use

Start operating the Spark with little to no training. Formulations are ready in seconds. Plus, they can be made on-demand in a sterile hood for immediate cell culture application.



NanoAssemblr Spark
Spark - Pipette Precursors



Spark - Cap




Spark - Insert




Spark - Push Start



Spark - Pipette Out



Spark - Dilute



Accelerate Proof of Concept
Kick-start the validation of novel treatment modalities or formulations. Rapidly explore materials and parameters with minimal consumption of materials.



Optimize Your Nanoparticle and Payload

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optimized_V2_Formulation Chart 2

Optimize mRNA Sequence and Nucleotide Modifications
Optimize mRNA Sequence

Screen Targeting Moieties


Screen Targeting Moieties

Get Started
To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.
NanoAssemblr Technology
Advanced Technology for Advanced Genetic Medicines

Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.



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An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into

each inlet of the NanoAssemblr cartridge


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Under laminar flow, the two phases do not immediately mix


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Microscopic features engineered into the channel reproducibly control the mixing of the two streams

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Rapid, controlled, homogenous mixing produces homogeneous nanoparticles



Spark Demo


NanoAssemblr Technology

Cartridges & Kits

NanoAssemblr Spark Cartridge

No cleaning or cleaning validation required: Cartridges are single-use and gamma irradiated for sterility. Available in packs of 20.

T-Cell Kit for mRNA Spark - Box and Vials

The GenVoy-ILM T Cell Kit for mRNA is an LNP reagent mix optimized for the delivery of mRNA into activated primary human T cells using mRNA-LNP.

Neuro9 siRNA Spark Kit - cropped

Neuro9 kits contain everything you need to encapsulate siRNA into clinically validated lipid nanoparticle (LNP) delivery systems. Kits include a proprietary ionizable cationic lipid.

Spark Brochure
The NanoAssemblr Spark has an operating nanoparticle formulation volume of 25 – 250 μL. By ensuring yields nearing 100%, the Spark is ideal for target validation screening and nanoparticle formulation development that involves scarce or expensive nucleic acid constructs and nanoparticle excipients.

Download Brochure
NanoAssemblr Spark Brochure

Resource Center

Application Note

March 15, 2022

Genome Editing of Human Primary T Cells with Lipid Nanoparticles

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Publication - Abstract

February 20, 2020

Nature Communications

Naturally-occurring Cholesterol Analogues in Lipid Nanoparticles Induce Polymorphic Shape and Enhance Intracel...

S. Patel, N. Ashwanikumar, E. Robinson, Y. Xia, C. Mihai, J.P. Griffith III, S. Hou, A.A. ...

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Publication - Summary

April 04, 2019

The Journal of Neuroscience

PTCD1 is Required for Mitochondrial Oxidative-phosphorylation: Possible Genetic Association with Alzheimer's D...

D. Fleck, L. Phu, E. Verschueren, T. Hinkle, M. Reichelt, T. Bhangale, B. Haley, Y. Wang, ...

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Application Note

January 16, 2019

mRNA Lipid Nanoparticles: Robust low-volume production for screening high-value nanoparticle materials

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Publication - Abstract

November 01, 2018


Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

B. Dejanovic, M.A. Huntley, A. De Mazière, W.J. Meilandt, T. Wu, K. Srinivasan and M. Shen...

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July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

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Resource Center 资源中心