Scientist Holding Small Formulation
Polymeric Nanoparticles

Polymeric NanoparticlePolymer-based nanoparticles can improve the efficacy, solubility, toxicity, bioavailability and pharmacokinetic profile of a drug molecule.

 

Numerous applications are being developed, including:

 

• Biodistribution of chemotherapeutic agents in tumors to reduce off-target toxicity and widen the therapeutic window
• Encapsulation and delivery of biomolecules for genetic medicine, gene-editing, and immunotherapy
• Encapsulation and co-delivery of multiple APIs and/or image contrast agents for combination drug therapy or theranostics


Overcoming Key Challenges in Advancing Polymer Nanoparticle Formulations


Challenges with Conventional Production Solutions with the NanoAssemblr® Platform
The formulation process has significant batch-to-batch variabilityorangeRightArrowReproducible polymer nanoparticle manufacturing process
Maintaining precise control over the particle size is difficultorangeRightArrowControl particle size through instrument parameters
Loading the nanoparticles is inefficientorangeRightArrowHigh drug loading efficiency in a one-step formulation process
Production is time consuming and labor-intensiveorangeRightArrowEnabling rapid, effortless polymer nanoparticle production and optimization
The manufacturing process is difficult to scale-uporangeRightArrowA seamless path to scaling up production

Key Benefits


Highly Reproducible Polymer Nanoparticle Manufacturing


Polymer ReproducibilityPLGA nanoparticles smaller than 100nm in size, produced in three separate batches by three independent operators, demonstrating interoperator and batch-to-batch consistency.


Control Particle Size through Convenient Instrument Parameters

PEG-PLGA Polymer Size Control
The size of PEG-PLGA block-copolymer micelles was tuned using the Total Flow Rate (TFR). Dial in parameters to achieve a specific size with the same polymer.


High Drug Loading Efficiency in a One-Step Formulation Process

Polymer Encapsulation Efficiency
PLGA nanoparticles formed in the presence of model drug Coumarin6 exhibit high encapsulation efficiency.


A Seamless Path to Scaling Up Production

PLGA Polymer Scalability
Formulation parameters optimized on the Benchtop (up to 15 mL) were transferred unchanged to the Blaze (up to 1000 mL) and the same size and PDI were achieved for PLGA-NPs. Samples can also be concentrated as desired using centrifugal filtration and tangential flow filtration.

How It Works

Rapid and Controlled Mixing




Polymers in a solvent are mixed with an aqueous phase in the NanoAssemblr® microfluidic cartridge where rapid, homogeneous mixing ensures particles are formed under consistent conditions. Computer controlled independent injection of both liquids allows mixing speed and mixing ratio to be easily dialed-in to systematically optimize particle formation parameters.

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To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Polymer Nanoparticle Resources

Publication - Abstract

May 08, 2020

Vaccines

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

G. Anderluzzi, G. Lou, S. Gallorini, M. Brazzoli, R. Johnson, D.T. O'Hagan, B.C. Baudner a...

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Publication - Abstract

December 31, 2019

Vaccines

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

C.B. Roces, M.T. Hussain, S.T. Schmidt, D. Christensen and Y. Perrie

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Publication - Abstract

April 08, 2021

Nanomaterials

Sesquiterpene-Loaded Co-Polymer Hybrid Nanoparticle Effects on Human Mast Cell Surface Receptor Expression, Gr...

N. Arizmendi, H. Qian, Y. Li and M. Kulka

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Publication - Abstract

March 15, 2021

Acta Biomaterilia

Nanoparticles for Delivery of Agents to Fetal Lungs

S.J. Ullrich, M. Freedman-Weiss, S. Ahle, D.H. Stitelman, et. al.

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Publication - Abstract

December 21, 2020

Molecular Therapy

Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA

A.K. Blakney, P.F. McKay, C.R. Bouton, K. Hu, K. Samnuan and R.J. Shattock

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Publication - Abstract

December 10, 2020

Journal of Orthopaedic Research

Diflunisal‐loaded Poly(propylene sulfide) Nanoparticles Decrease S. aureus‐mediated Bone Destruction During Os...

C.A. Ford, T.J. Spoonmore, M.K. Gupta, C.L. Duvall, S.A. Guelcher and J.E. Cassat

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