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Polymeric Nanoparticles
Polymer-based nanoparticles can improve the efficacy, solubility, toxicity, bioavailability and pharmacokinetic profile of a drug molecule.
Numerous applications are being developed, including:
• Biodistribution of chemotherapeutic agents in tumors to reduce off-target toxicity and widen the therapeutic window
• Encapsulation and delivery of biomolecules for genetic medicine, gene-editing, and immunotherapy
• Encapsulation and co-delivery of multiple APIs and/or image contrast agents for combination drug therapy or theranostics
Overcoming Key Challenges in Advancing Polymer Nanoparticle Formulations
| Challenges with Conventional Production | Solutions with the NanoAssemblr® Platform | |
| The formulation process has |  | Reproducible polymer nanoparticle manufacturing process |
| Maintaining precise control over the particle size is difficult | | Control particle size through instrument parameters |
| Loading the nanoparticles is inefficient | | High drug loading efficiency in a one-step formulation process |
| Production is | | Enabling rapid, effortless polymer nanoparticle production and optimization |
| The manufacturing process is difficult to scale-up | | A seamless path to scaling up production |
Highly Reproducible Polymer Nanoparticle Manufacturing
PLGA nanoparticles smaller than 100nm in size, produced in three separate batches by three independent operators, demonstrating interoperator and batch-to-batch consistency.Control Particle Size through Convenient Instrument Parameters
The size of PEG-PLGA block-copolymer micelles was tuned using the Total Flow Rate (TFR). Dial in parameters to achieve a specific size with the same polymer.
High Drug Loading Efficiency in a One-Step Formulation Process
PLGA nanoparticles formed in the presence of model drug Coumarin6 exhibit high encapsulation efficiency.
A Seamless Path to Scaling Up Production
Formulation parameters optimized on the Benchtop (up to 15 mL) were transferred unchanged to the Blaze (up to 1000 mL) and the same size and PDI were achieved for PLGA-NPs. Samples can also be concentrated as desired using centrifugal filtration and tangential flow filtration.
Polymers in a solvent are mixed with an aqueous phase in the NanoAssemblr® microfluidic cartridge where rapid, homogeneous mixing ensures particles are formed under consistent conditions. Computer controlled independent injection of both liquids allows mixing speed and mixing ratio to be easily dialed-in to systematically optimize particle formation parameters.
Polymer Nanoparticle Resources
Publication - Abstract
May 08, 2020
Vaccines
Publication - Abstract
December 31, 2019
Vaccines
Publication - Abstract
December 10, 2020
Journal of Orthopaedic Research
Publication - Abstract
December 07, 2020
Journal of Controlled Release
Publication - Abstract
November 02, 2020
Journal of Controlled Release
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