Publication - Abstract
Feb 15, 2019
International Journal of Nanomedicine
November 10, 2016
Liposomes have been the centre of attention in research due to their potential to act as drug delivery systems. Although its versatility and manufacturing processes are still not scalable and reproducible. In this study, the microfluidic mixing method for liposomes preparation is presented. DMPC and DSPC liposomes containing two different lipid/cholesterol ratios (1:1 and 2:1) are prepared. Results from this preparation process were compared with the film hydration method in order to understand benefits and drawbacks of microfluidics. Liposomes characterization was evaluated through stability studies, encapsulation efficacy and drug release profiles of hydrophilic and lipophilic compounds. Stability tests were performed during 3 weeks and the liposomes properties of the most stable formulations were determined using Infrared Microscopy and Atomic Force Microscopy. Microfluidic allows loading of drugs and assembly in a quick single step and the chosen flow ratio for liposomes formulation plays a fundamental role for particle sizes. One hydrophilic and one lipophilic compounds were incorporated showing how formulation and physic-chemical characteristics can influence the drug release profile.
Publication - Abstract
Feb 15, 2019
International Journal of Nanomedicine
Publication - Abstract
Mar 18, 2021
European Journal of Pharmaceutics and Biopharmaceutics
Use of the frit-inlet channel improves MD-AF4 analysis of LNP-RNA.
A robust method for AF4 separation of LNP-RNA has been developed and tested on two different platform.
The method meets all the ISO stan...