Microfluidic-Controlled Manufacture of Liposomes for the Solubilisation of a Poorly Water Soluble Drug


Authors: E. Kastner, V. Verma, D. Lowry and Y. Perrie

Journal: International Journal of Pharmaceutics

DOI: 10.1016/j.ijpharm.2015.02.063

Publication - Abstract

May 15, 2015

Abstract:

Besides their well-described use as delivery systems for water-soluble drugs, liposomes have the ability to act as a solubilizing agent for drugs with low aqueous solubility. However, a key limitation in exploiting liposome technology is the availability of scalable, low-cost production methods for the preparation of liposomes. Here we describe a new method, using microfluidic mixing, to prepare liposomal solubilizing systems which can incorporate low solubility drugs (in this case propofol). The setup, based on a chaotic advection micromixer, showed high drug loading (41 mol%) of propofol as well as the ability to manufacture vesicles with at prescribed sizes (between 50 and 450 nm) in a high-throughput setting. Our results demonstrate the ability of merging liposome manufacturing and drug encapsulation in a single process step, leading to an overall reduced process time. These studies emphasize the flexibility and ease of applying lab-on-a-chip microfluidics for the solubilization of poorly water-soluble drugs.

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