Publication - Abstract
Jan 28, 2021
Vaccines
This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical a...
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Publication - Abstract
Dec 21, 2020
Molecular Therapy
Abstract
Self-amplifying RNA (saRNA) is a cutting-edge platform for both nucleic acid vaccines and therapeutics. saRNA is self-adjuvanting, as it activates types I and III interferon (IFN), which enhances the immunogenicity of RNA vaccines but can also lead to inhibition...Publication - Abstract
Jul 01, 2020
Journal of Controlled Release
Self-amplifying RNA (SAM) represents a versatile tool that can be used to develop potent vaccines, potentially able to elicit strong antigen-specific humoral and cellular-mediated immune responses to virtually any infectious disease. To protect the SAM from degradation and achiev...
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Publication - Abstract
May 08, 2020
Vaccines
messenger RNA (mRNA)-based vaccines combine the positive attributes of both live-attenuated and subunit vaccines. In order for these to be applied for clinical use, they require to be formulated with delivery systems. However, there are limited in vivo studies which...
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Publication - Abstract
Feb 25, 2021
Molecular Cancer
mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. mRNA cancer ...
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VIDEOS & WEBINARS
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Webinar
Mar 31, 2020
Dr. Andy Geall will walk us through the history and commercial mRNA vaccine landscape, the background to the SAM (self-amplifying mRNA) vaccine platform and non-viral delivery. He will also discuss preclinical data of the application in pandemic influenza, and the translation fro...