Microfluidic Synthesis Control Technology and Its Application in Drug Delivery, Bioimaging, Biosensing, Environmental Analysis and Cell Analysis


Authors: C.T. Kung, H. Gao, C.Y. Lee, Y.N. Wang, W. Dong C.H. Ko, G. Wang and L.M. Fu

Journal: Chemical Engineering Journal

DOI: 10.1016/j.cej.2020.125748

Publication - Abstract

June 15, 2020

Abstract

• Flow control mechanisms used in microfluidic synthesis platforms have been discussed.

• Review focuses on proposals for applications of drug delivery, bioimaging, biosensing, and cellular analysis.

• Review provides a detailed overview of advances in microfluidic synthesis technology field over the past years.

 


Abstract

Nanomaterials have attracted significant attention in biomedical and environmental science in recent years due to their unique thermal, optical, electrical and magnetic properties. The properties of nanomaterials are highly correlated with their size and morphology. Consequently, efficient methods for synthesizing nanomaterials with a consistent size and shape are urgently required. Compared to conventional large-scale synthesis systems, microfluidic systems offer a far better control over the growth, nucleation and reaction conditions. As such, microfluidic synthesis has emerged as a key enabling technology for the rapid, low cost and reliable preparation of nanomaterials with complex properties and functions. This review provides a detailed overview of advances in the microfluidic synthesis technology field over the past five years. The review commences by describing the main microfluidic control mechanisms and microfluidic synthesis of particles. Some of the more common applications of microfluidic synthesized micro and nanomaterials are then introduced, including drug delivery, bioimaging, biosensing, environmental analysis, and cell analysis. The review concludes with a brief overview of the challenges facing the microfluidic synthesis field in the coming years, together with possible research directions aimed at overcoming these challenges.

Advanced Search

close
  • Publications
  • Application Notes
  • Posters
  • Workshops
  • Videos & Webinars
  • Articles
Search

Browse by Category

  • Application
    • Diagnostic and Imaging
    • Genetic Medicine
    • Hematology
    • Metabolic Disorders
    • Neuroscience
    • Oncology
    • Skeletal Disorders
    • Targeted Drug Delivery
    • Vaccines
    • Other Applications
    • Cell therapy
  • Formulation
    • Liposomes
    • Nucleic Acid Lipid Nanoparticles
    • Polymeric Nanoparticles
    • Other Formulations
  • Payload
    • DNA
    • microRNA
    • mRNA
    • siRNA
    • Small Molecule Drugs
    • Other Payloads


related content

Publication - Abstract

Technological Challenges in the Preclinical Development of an HIV Nanovaccine Candidate

T.G. Dacoba, L. Ruiz-Gatón, A. Benito. M. Klein, D. Dupin, M. Luo, M. Menta, D. Teijeiro-Osorio, I. Loinaz, M.J. Alonso and J. Crecente-Campo

Despite a very active research in the field of nanomedicine, only a few nano-based drug delivery systems have reached the market. The “death valley” between research and commercialization has been partially attributed to the limited characterization and reproducibilit...
Read More


Publication - Abstract

Therapeutic Shutdown of HBV Transcripts Promotes Reappearance of the SMC5/6 Complex and Silencing of the Viral genome In Vivo

L. Allweiss, K. Giersch, A. Pirosu, T. Volz, R.C. Muench, R.K. Beran, S. Urban, H. Javanbakht, S.P. Fletcher, M. Lütgehetmann and M. Dandri

These results reveal that therapeutics abrogating all HBV transcripts including HBx promote epigenetic suppression of the HBV minichromosome, whereas strategies protecting the human hepatocytes from reinfection are needed to maintain cccDNA silencing.
Read More


Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.