Advances in Development of mRNA-Based Therapeutics


Authors: L. Huang, L. Zhang, W. Li, S. Li, J. Wen, H. Li and Z. Liu

Journal: Current Topics in Microbiology and Immunology

DOI: https://doi.org/10.1007/82_2020_222

Publication - Abstract

July 19, 2020

Other Applications Nucleic Acid Lipid Nanoparticles Polymeric Nanoparticles
Recently, mRNA-based therapeutics have been greatly boosted since the development of novel technologies of both mRNA synthesis and delivery system. Promising results were showed in both preclinical and clinical studies in the field of cancer vaccine, tumor immunotherapy, infectious disease prevention and protein replacement therapy. Recent advancements in clinical trials also encouraged scientists to attempt new applications of mRNA therapy such as gene editing and cell programming. These studies bring mRNA therapeutics closer to real-world application. Herein, we provide an overview of recent advances in mRNA-based therapeutics.

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