Join us on July 19th for the Precision NanoSystems' Symposium, a virtual event exploring the evolving manufacturing landscape of genomic medicines. This live event features industry leaders who will share strategic insights for navigating the challenges and opportunities for clinical and commercial production of mRNA therapeutics.

This series of panel discussions and presentations is free to attend.

Date: Wednesday, July 19
Time: 8:00am-11:00am PT  |  11:00am-2:00pm ET  |  5:00pm-8:00pm CET

Keynote Panel Discussion: Clinical and Commercial Manufacturing of mRNA Therapeutics: Opportunities and Challenges
Presentation: Standardizing Scale-up: Insights into Producing Clinical and Commercial RNA-LNP Drug Products
Panel Discussion: Maximizing Yield and Purity in RNA-LNP Downstream Processing

Register now to save the date!

9:00am PT | 12:00pm ET | 6:00pm CET 

Speaker: Dr. Ian Villamagna, Senior Field Application Scientist, Precision NanoSystems

Over the last few years, there was an unprecedented demand on biopharma manufacturers to produce an mRNA vaccine in an accelerated timeline. Given the considerable number of variables throughout the production workflow, new flexible and robust manufacturing solutions are required to accelerate scale-up and standardize GMP manufacturing processes.

This presentation will share: 

- Insights into new platform technologies that increase efficiency to enable rapid scale-up and large-scale manufacturing of mRNA vaccines and therapeutics 
- How to improve operational flexibility by expanding single-use technology to LNPs 
- Strategies to increase manufacturing capacity during clinical and commercial production

10:00am PT | 1:00pm ET | 7:00pm CET 

Downstream processing of RNA-LNPs can often be a bottleneck during scale-up to clinical production. Maximizing yield and purity is a key concern along with controlling critical process parameters. This panel discussion will examine tangential flow filtration (TFF), an essential step in post-formulation purification of RNA-LNPs, including: 

- The essential steps for designing and optimizing downstream processing of RNA-LNPs  
- Challenges with scaling TFF processes and controlling key parameters such as filtration cartridge, membrane material and transmembrane pressure 
- Strategies to achieve high flux and throughput while maintaining critical quality attributes including size, morphology and yield