An Update on Self-Amplifying mRNA Vaccine Development

Publication - Abstract

Feb 26, 2016
Scientific Reports

Effects of Local Structural Transformation of Lipid-Like Compounds on Delivery of Messenger RNA

B. Li, X. Luo, B. Deng, J.B. Giancola, D.W. McComb, T.D. Schmittgen and Y. Dong

mRNA Nucleic Acid Lipid Nanoparticles Genetic Medicine

Lipid-like nanoparticles (LLNs) have shown great potential for RNA delivery. Lipid-like compounds are key components in LLNs. In this study, we investigated the effects of local structural transformation of lipid-like compounds on delivery of messe...

Publication - Abstract

May 31, 2019
Vaccine

mRNA Vaccines Against H10N8 and H7N9 Influenza Viruses of Pandemic Potential Are Immunogenic and Well Tolerated in Healthy Adults in Phase 1 Randomized Clinical Trials

R.A. Feldman, R. Fuhr, I. Smolenov, A. Ribeiro, L. Panther, M. Watson, J.J. Senn, M. Smith, Ö. Almarsson, H.S. Pujar, M.E. Laska, J. Thompson, T. Zaks, and G. Ciaramella

Vaccines Nucleic Acid Lipid Nanoparticles mRNA

Two randomized, placebo-controlled, double-blind, phase 1 clinical trials enrolled participants between December 2015 and August 2017 at single centers in Germany (H10N8) and USA (H7N9). Healthy adults (ages 18–64 years for H10N8 study; 18–49 years for H7N9 study) par...