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The
NanoAssemblr™
Benchtop
Develop Future Nanomedicines
benchtop
double-microbes
Overcome key challenges
in nanomedicine development
with the Benchtop.
oustanding repproducibility

Computer control removes batch-to-batch and user variability

intuitive work flow

Advanced microfluidics are simplified with easy connections, and visual software


controlled assembly

Tune particle size with precise control over fluid flow rates

 
versatile

Formulate small molecules, peptides and nucleic acids into lipid, polymer or hybrid nanoparticles, and more.

speedy and efficient

Formulation runs require less than a minute. 30 - 40 formulations can be completed in a day for rapid optimization

 
scalable

Easily scale between 1mL and 15mL formulations on the Benchtop. Optimized formulations can be transfered to advanced preclinical and clinical scale with the Blaze™ and 8x Scale-up systems

Easily optimize
nanoparticle size
Use simple software parameters such as Total Flow Rate (TFR) and Flow Rate Ratio (FRR) to fine tune particle size.
Optimize liposomal drug delivery systems first-chart
Develop polymeric drug delivery systems second-chart
Robust,
reproducible
process
Minimizing process variability isolates the effects of materials, solvent choice, and concentrations on desired outcomes, enabling rational formulation design.
Batch-to-Batch Reproducibility from Independent UsersReproducibility & Control

Isolate Effects of Formulation Parameters 

Formulation Parameters Website Ver

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch
Advanced Technology for
Advanced Nanomedicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly thats scalable from discovery to the clinic.

1

An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge

2

Under laminar flow, the two phases do not immediately mix

3

Microscopic features engineered into the channel reproducibly control the mixing of the two streams

4

Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
nanomedicine-technology
Videos

 

Overview

 

NanoAssemblr Technology

 

Benchtop Demo

Benchtop Cartridges
NanoAssemblr™ Benchtop cartridges are semi-disposible and compatible with a wide range of solvents to make a diverse array of nanomedicine formulations. Cartridges are available in packs of 5.
Benchtop Cartridge
Benchtop Brochure
Benchtop Brochure_ThumbThe NanoAssemblr Benchtop system is designed for rapid prototyping of novel nanoparticle formulations of 1 to 15mL, that would be difficult to make with alternative manufacturing methods. Software enables the control of input mixing parameters for optimizing particle characteristics such as size and encapsulation efficiency.


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Resource Center

Poster

August 01, 2018

Microfluidics-based Manufacture of PEG-b-PLGA Block Copolymer Nanoparticles for the Delivery of Small Molecule Therapeutics

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Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr™ Platform

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Poster

June 11, 2018

Rapid development and seamless scale-up of genetic nanomedicines

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Publication - Abstract

June 01, 2018

Biological and Pharmaceutical Bulletin

The Use of an Efficient Microfluidic Mixing System for Generating Stabilized Polymeric Nanoparticles for Controlled Drug Release

Y Morikawa, T Tagami, A Hoshikawa, T Ozeki

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Publication - Abstract

May 25, 2018

Multiple Myeloma

Microfluidic Assembly of Liposomes with Tunable Size and Coloading Capabilities

JR Hoffman, E Tasciotti, R Molinaro

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Publication - Abstract

April 18, 2018

Journal of Leukocyte Biology

Lipofection of Plasmid DNA into Human Mast Cell Lines using Lipid Nanoparticles Generated by Microfluidic Mixing

Duguay, B. A., Huang, K. W., & Kulka, M

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Resource Center