Mastering the Tools: Natural versus Artificial Vesicles in Nanomedicine


Authors: L. Leggio, G. Arrabito, V. Ferrara, S. Vivarelli, G. Paterno, B. Marchetti, B. Pignataro and N. Iraci

Journal: Advanced Healthcare Materials

DOI: 10.1002/adhm.202000731

Publication - Abstract

August 31, 2020

Abstract

Naturally occurring extracellular vesicles and artificially made
vesicles represent important tools in nanomedicine for the efficient delivery of
biomolecules and drugs. Since its first appearance in the literature 50 years
ago, the research on vesicles is progressing at a fast pace, with the main goal
of developing carriers able to protect cargoes from degradation, as well as to
deliver them in a time- and space-controlled fashion. While natural occurring
vesicles have the advantage of being fully compatible with their host, artificial
vesicles can be easily synthetized and functionalized according to the target to
reach. Research is striving to merge the advantages of natural and artificial
vesicles, in order to provide a new generation of highly performing vesicles,
which would improve the therapeutic index of transported molecules. This
progress report summarizes current manufacturing techniques used to
produce both natural and artificial vesicles, exploring the promises and pitfalls
of the different production processes. Finally, pros and cons of natural versus
artificial vesicles are discussed and compared, with special regard toward the
current applications of both kinds of vesicles in the healthcare field.

Advanced Search

close
  • Publications
  • Application Notes
  • Posters
  • Workshops
  • Videos & Webinars
  • Blog Posts
Search

Browse by Category

  • Application
    • Diagnostic and Imaging
    • Genetic Medicine
    • Hematology
    • Metabolic Disorders
    • Neuroscience
    • Oncology
    • Skeletal Disorders
    • Targeted Drug Delivery
    • Vaccines
    • Other Applications
    • Cell therapy
  • Formulation
    • Liposomes
    • Nucleic Acid Lipid Nanoparticles
    • Polymeric Nanoparticles
    • Other Formulations
  • Payload
    • DNA
    • microRNA
    • mRNA
    • siRNA
    • Small Molecule Drugs
    • Other Payloads


related content

Publication - Abstract

Lipid nanoparticles (LNPs) containing short interfering RNA (LNP-siRNA) and optimized ionizable cationic lipids are now clinically validated systems for silencing disease-causing genes in hepatocytes following intravenous administration. However, t...

Read More


Publication - Summary

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

A.K.K. Leung, I.M. Hafez, S. Baoukina, N.M. Belliveau, I.V. Zhigaltsev, E. Afshinmanesh, D.P. Tieleman, C.L. Hansen, M.J. Hope, and P.R. Cullis

Gene therapy can be the solution to treatment of many undruggable conditions. RNA interference (RNAi) has been identified as a powerful gene therapy tool which can regulate and improve defective biological pathways through downregulation of target ...

Read More


Sign Up and Stay Informed
Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.