Publication - Abstract
Nov 29, 2018
International Journal of Pharmaceutics
November 21, 2016
A pH-sensitive molecular switch able to change its conformation upon protonation at endosomal pH values is embedded into the structure of cationic lipidoid materials, thus conferring endosomal escape properties. Involvement of the conformational switch in the endosomal escape process was confirmed and leading material identified was able to induce efficient gene knockdown both in vitro and in vivo. The lipid nanoparticles reported here are promising for therapeutic applications and this work could serve as a template for future design of stimulus-responsive (ionic, redox, light) molecular switch for drug and gene delivery.
Publication - Abstract
Nov 29, 2018
International Journal of Pharmaceutics
Publication - Summary
Dec 28, 2016
Nanomedicine: Nanotechnology, Biology and Medicine
Advances in molecular biology have led to great interest and potential in applying gene therapy to correct/ regulate expression of disease-related genes that are otherwise undruggable. Gene therapy is one of the great pillars of the newly emerging ...