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Formulation
Solutions

Formulation Solutions leverages Precision NanoSystems’ research facilities, technical team and NanoAssemblr® Platform to design flexible, custom nanomedicine formulation and nanoparticle manufacturing process development solutions.
Overview

Formulation Solutions projects span the entire nanoparticle formulation development continuum—from proof-of-concept nanoparticle formulations in early discovery to advancing lead candidate development in scale-up, to optimization and technology transfer of nanoparticle manufacturing processes to CMO/manufacturing sites for cGMP production.

The Precision NanoSystems team uses proprietary NanoAssemblr® microfluidic technology to develop optimized process parameters for the manufacture of lipid or polymer-based nanomedicines that meet target specifications.

 

Formulation Solution Experts


Examples of Formulation Solutions Projects and Deliverables

• Nanoparticle formulation(s) suitable for proof-of-concept and pre-clinical testing

• Manufacturing support for NanoAssemblr® Benchtop and Blaze users

• Tech transfer plan and manufacturing support to CMO/manufacturing site (for 8X NanoAssemblr® Scale-Up System)

• Standard Operating Protocols for nanoparticle manufacture using the NanoAssemblr® platform and products

• Standard Operating Protocols for downstream (ultrafiltration and diafiltration) processing of nanoparticles

• Analysis of nanoparticle physicochemical and biological properties

The Formulation Solutions team collaborates with customers to develop a well-defined project plan, with identified project deliverables, timeline, and budget.


Talk to a Formulations Expert

Formulation Solutions projects span the entire nanoparticle formulation development continuum—from early discovery proof-of-concept nanoparticle formulations to CMO/manufacturing sites for cGMP production.

Talk to a Formulations Expert







Brochure
Formulation Solutions BrochureFor more information, please follow the link below for our Formulation Solutions brochure.

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Resource Center

Publication - Abstract

November 29, 2018

International Journal of Pharmaceutics

Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-lin...

N. Forbes, MT. Hussain, ML. Briuglia, DY. Edwards, JH. terHorst, N. Szita, Y. Perrie

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Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

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Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr® Platform

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Publication - Abstract

April 26, 2018

Small Methods

State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M.

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Publication - Abstract

February 27, 2018

Cell Reports

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

J. Finn, A. Smith, M. Patel, L. Shaw, M. Youniss, J. Heteren, T. Dirstine, C. Ciullo, R. Lescarbeau, J. Seitzer, R. Shah...

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Publication - Abstract

November 29, 2018

Carbohydrate Polymers

N-oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing...

E. Bartheldyová, et al.

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