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Formulation
Solutions

Formulation Solutions leverages Precision NanoSystems’ research facilities, technical team and NanoAssemblr® Platform to design flexible, custom nanomedicine formulation and nanoparticle manufacturing process development solutions.
Overview

Formulation Solutions projects span the entire nanoparticle formulation development continuum—from proof-of-concept nanoparticle formulations in early discovery to advancing lead candidate development in scale-up, to optimization and technology transfer of nanoparticle manufacturing processes to CMO/manufacturing sites for cGMP production.

The Precision NanoSystems team uses proprietary NanoAssemblr® microfluidic technology to develop optimized process parameters for the manufacture of lipid or polymer-based nanomedicines that meet target specifications.

 

Formulation Solution Experts


Examples of Formulation Solutions Projects and Deliverables

• Nanoparticle formulation(s) suitable for proof-of-concept and pre-clinical testing

• Manufacturing support for NanoAssemblr® Benchtop and Blaze users

• Tech transfer plan and manufacturing support to CMO/manufacturing site (for NanoAssemblr® GMP System)

• Standard Operating Protocols for nanoparticle manufacture using the NanoAssemblr® platform and products

• Standard Operating Protocols for downstream (ultrafiltration and diafiltration) processing of nanoparticles

• Analysis of nanoparticle physicochemical and biological properties

The Formulation Solutions team collaborates with customers to develop a well-defined project plan, with identified project deliverables, timeline, and budget.


Talk to a Formulations Expert

Formulation Solutions projects span the entire nanoparticle formulation development continuum—from early discovery proof-of-concept nanoparticle formulations to CMO/manufacturing sites for cGMP production.

Talk to a Formulations Expert







Brochure
Formulation Solutions BrochureFor more information, please follow the link below for our Formulation Solutions brochure.

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Resource Center

Publication - Summary

May 18, 2019

Annals of Hematology

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo

N. Jyotsana, A. Sharma, A. Chaturvedi, et al.

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Publication - Summary

May 17, 2019

Science Immunology

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

N. Kose, J.M. Fox, G. Sapparapu, et al.

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Publication - Summary

April 04, 2019

The Journal of Neuroscience

PTCD1 is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease

D. Fleck, L. Phu, E. Verschueren, T. Hinkle, M. Reichelt, T. Bhangale, B. Haley, Y. Wang, R. Graham, D.S. Kirkpatrick, M...

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Publication - Summary

February 07, 2019

Nano Research

Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast can...

C. Zhang, X. Zhang, W. Zhao, C. Zeng, W. Li, B. Li, X. Luo, J. Li, J. Jiang, B. Deng, D.W. McComb, Y. Dong

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Application Note

January 16, 2019

mRNA Lipid Nanoparticles: Robust low-volume production for screening high-value nanoparticle materials

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Publication - Summary

September 24, 2018

Nucleic Acid Therapeutics

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

R. Jain, JP. Frederick, EY. Huang, KE. Burke, DM. Mauger, EA. Andrianova, SJ. Farlow, S. Siddiqui, J. Pimentel, K. Cheun...

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