Reproducible Production of Sub-100 nm PLGA Nanoparticles using the NanoAssemblr™ Microfluidic Platform
Polymeric nanoparticles can be used for delivery of a variety of drugs. The current nanoparticle manufacturing methods lack batch-to-batch reproducibility, and are unable to generate narrow particle size distributions. This leads to inconsistencies in nanoparticle quality that hinder the clinical success of the formulation. Here, we present a novel method for the manufacture of polymeric nanoparticles using a microfluidic technology that addresses these key manufacturing concerns.
Encapsulation of drug molecules with a polymeric nanocarrier can change the pharmacokinetic profile of the drug, enabling it to reach its target site. It is normally critical that the nanoparticles are loaded with sufficient amounts of the payload so that the intended dose is delivered and the therapeutic action is attained. However, high drug encapsulation efficiencies may be difficult to achieve with current techniques. The NanoAssemblr platform provides researchers with a means of formulating polymeric nanoparticles and achieve exceptionally high encapsulation efficiencies.
The NanoAssemblr technology platforms enables researchers to create polymeric nanoparticles while fine tuning the size and population dispersity. This application note explore a few examples of PLGA nanoparticles formulated by the NanoAssemblr Benchtop.
Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release
Correia MG, Briuglia ML, Niosi F, Lamprou DA. Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release. International Journal of Pharmaceutics. (2017) doi: 10.1016/j.ijpharm.2016.11.025
Systemic delivery of factor IX messenger RNA for protein replacement therapy
Ramaswamy S, Tonnu N, Tachikawa K, Limphong P, Vega JB, Karmali PP, Chivukula P, Verma IM. Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proceedings of the National Academy of Sciences. (2017) doi:10.1073/pnas.1619653114
The effects of hydration media on the characteristics of non-ionic surfactant vesicles (NISV) prepared by microfluidics
Obeid MA, Khadra I, Mullen AB, Tate RJ, Ferro VA. The effects of hydration media on the characteristics of non-ionic surfactant vesicles (NISV) prepared by microfluidics. International Journal of Pharmaceutics. (2017) doi: 10.1016/j.ijpharm.2016.11.015 Non-ionic surfactant vesicles (NISV) are colloidal particles that provide a useful delivery system for drugs and vaccines. One of the methods that is […]