Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses
Bahl K, Senn JJ, Yuzhakov O, Bulychev A, Brito LA, Hassett KJ, Laska ME, Smith M, Almarsson Ö, Thompson J, Ribeiro AM. Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses. Molecular Therapy (2017) doi: 10.1016/j.ymthe.2017.03.035
Reproducible Production of Sub-100 nm PLGA Nanoparticles using the NanoAssemblr™ Microfluidic Platform
Polymeric nanoparticles can be used for delivery of a variety of drugs. The current nanoparticle manufacturing methods lack batch-to-batch reproducibility, and are unable to generate narrow particle size distributions. This leads to inconsistencies in nanoparticle quality that hinder the clinical success of the formulation. Here, we present a novel method for the manufacture of polymeric nanoparticles using microfluidic mixing technology that addresses these key manufacturing concerns.
Encapsulation of drug molecules with a polymeric nanocarrier can change the pharmacokinetic profile of the drug, enabling it to reach its target site. It is normally critical that the nanoparticles are loaded with sufficient amounts of the payload so that the intended dose is delivered and the therapeutic action is attained. However, high drug encapsulation efficiencies may be difficult to achieve with current techniques. The NanoAssemblr platform provides researchers with a means of formulating polymeric nanoparticles and achieve exceptionally high encapsulation efficiencies.
The NanoAssemblr technology platforms enables researchers to create polymeric nanoparticles while fine tuning the size and population dispersity. This application note explore a few examples of PLGA nanoparticles formulated on the NanoAssemblr Benchtop.
Microfluidic Manufacturing of Phospholipid Nanoparticles: Stability, Encapsulation Efficacy, and Drug Release
Correia MG, Briuglia ML, Niosi F, Lamprou DA. Microfluidic manufacturing of phospholipid nanoparticles: Stability, encapsulation efficacy, and drug release. International Journal of Pharmaceutics. (2017) doi: 10.1016/j.ijpharm.2016.11.025