Publication - Abstract
Nov 29, 2018
Carbohydrate Polymers
E. Bartheldyová, P.T. Knotigová, K. Zachová and J. Turánek et al.
New synthetic aminooxy lipid was designed and synthesized as a building block for the formulation of functionalised nanoliposomes (presenting onto the outer surface of aminooxy groups) by microfluidic mixing. Orthogonal binding of cellular mannan (Candida glabrata (CCY 26-20-1) o...
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Publication - Abstract
May 13, 2021
Nature Communications
C. Hunt, S.A. Hartford, G. Gong, et al
The paper demonstrates PNI's mRNA-LNP as highly capable of inducing strong levels of upregulation in target genes with activation levels six to nine fold dependent on amount of gRNA packaged. The paper validates the SAM system in mice as a suitable in vivo model encompassing both...
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