Publication - Abstract
Nov 21, 2016
Nanoscale
W. Viricel, S. Poirier, A. Mbarek, R.M. Derbali, G. Mayer and J. Leblond
A pH-sensitive molecular switch able to change its conformation upon protonation at endosomal pH values is embedded into the structure of cationic lipidoid materials, thus conferring endosomal escape properties. Involvement of the conformational switch in the endosomal escape pro...
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Publication - Abstract
Jun 05, 2020
Journal of Controlled Release
S. Woods, L.M. O'Brien, W. Butcher, J.E. Preston, A.R. Georgian, E.D. Williamson, F.J. Salguero, F. Modino, N.J. Abbott, C.W. Roberts and R.V. D'Elia
The field of brain drug delivery faces many challenges that hinder development and testing of novel therapies for clinically important central nervous system disorders. Chief among them is how to deliver large biologics across the highly restrictive blood-brain barrier. Non-ionic...
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