Modification of Liposomal Surface by Polysaccharides: Preparation, Characterization, and Application for Drug Targeting


Authors: J. Turánek, J. Mašek, M. Raška, M. Ledvina, E. Paulovičová, F. Hubatka and J. Kotouček

Journal: Functional Polysaccharides for Biomedical Applications

DOI: 10.1016/B978-0-08-102555-0.00013-3

Publication - Abstract

July 11, 2019

Abstract

Polysaccharides are indispensable macromolecules widely used in pharmaceutical industry. Hyaluronic acid, mannans, cellulose derivatives, alginates, and dextrans are applied for the preparation of polysaccharide-modified nanoparticles to develop targeted delivery systems for drugs, theranostics, vaccines, and immunotherapeutics. Liposomes represent the most versatile nanoparticles and liposomal products have already found clinical applications, due to their biocompatibility, biodegradability, low toxicity, and ability to internalize substances with different physical-chemical properties. Modification of liposomal surface with polysaccharides is a special part of bioconjugation chemistry and application of click chemistry for orthogonal binding of polysaccharides onto liposomal surface is a new challenging approach for the development of drug and vaccine targeting nanosystems. New technologies for laboratory and industrial production of polysaccharide-modified liposomes can be developed by combination of microfluidics technology integrated together with other processes (dialysis, click chemistry, photochemistry, and drug loading) into a single device by utilizing so-called Lab-on-Chip technology enabling automated high-throughput processes for the production of liposome-based products.

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