What is

Revolutionizing Medicine
Following biologics, nanomedicines represent the next era in drug innovation. Current research has demonstrated improved performance, reduced side effects, and revolutionary new treatment strategies like personalized medicine.

Several nanomedicines are available on the market such as Doxil, Visudyne, and Vyxeos. The most clinically advanced RNA medicine—Patisiran—is enabled by lipid nanoparticle (LNP) technology.

What is Nanomedicine Size Chart

Commonly, nanomedicines consist of active pharmaceutical ingredients (API) such as small molecules or biologics packaged into nano-sized carriers made of excipients like lipids and polymers. Nanoparticles tend to be smaller than cells but larger than most biomolecules, so the nanomedicine can interact with the body differently than the API alone. The properties of nanomedicines can be designed to control when and where in the body the API is available.

What is Nanomedicine Active Ingredients

Applications of Nanomedicine
By packaging a variety of active pharmaceutical ingredients (API) into nanoparticles, drug innovators aim to:

Protect API
Protect the API
Control API
Control API Release
Alter API
Alter Biodistribution
Target Drug Delivery
Target drug delivery
to the site of disease
Soluble APIs
Enhance solubility
and bioavailability

Nanomedicines are at the Heart of Next-Generation Medicines
Nanomedicines currently being developed, allow treatment of otherwise "undruggable" targets to address unmet medical needs through revolutionary new strategies:

Nanomedicine: Future of Medicine

The Challenge

Using traditional methodologies, drug researchers face significant challenges in producing nanomedicines for R&D, clinical testing, and commercial manufacture.


Lipid Nanoparticle v Small Molecule


Nanoparticles consist of millions of molecules that need to come together and work in concert, and traditional production methods adapted from processes developed over decades for small molecule drugs do not adequately address the unique needs of nanomedicine production.

Traditional Methods:

Lack Consistency Nanomedicine: Quality Comparison

Are laborious/slow/low throughput Doxil process:
10 Steps
17 Process vessels
5 Days

Are difficult to scale Nanomedicine: Difficult to Scale

Require expertise/skill Nanomedicine: Requires Skill

Advanced Solutions for Advanced Medicines
Precision NanoSystems is enabling drug innovators to overcome unique challenges in creating transformative medicine by making purpose-designed manufacturing technology and unique nanomedicine expertise available to support all stages of nanomedicine development.
Liposome, LNP, Polymer NP, Emulsion

Resource Center

Publication - Abstract

November 29, 2018

International Journal of Pharmaceutics

Rapid and scale-independent microfluidic manufacture of liposomes entrapping protein incorporating in-line purification and at-lin...

N. Forbes, MT. Hussain, ML. Briuglia, DY. Edwards, JH. terHorst, N. Szita, Y. Perrie

Read More


July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

Read More PDF

Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr® Platform

Read More PDF

Publication - Abstract

April 26, 2018

Small Methods

State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M.

Read More

Publication - Abstract

February 27, 2018

Cell Reports

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

J. Finn, A. Smith, M. Patel, L. Shaw, M. Youniss, J. Heteren, T. Dirstine, C. Ciullo, R. Lescarbeau, J. Seitzer, R. Shah...

Read More

Publication - Abstract

November 29, 2018

Carbohydrate Polymers

N-oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing...

E. Bartheldyová, et al.

Read More
Resource Center

Stay Informed

Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.