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GenVoy-ILM™

Non-Viral LNP Delivery for RNA

GenVoy-ILM Webinar 2020

 

Watch our experts demonstrate how GenVoy-ILM, an accessible non-viral lipid formulation for gene delivery, is being used to reduce barriers faced when developing RNA treatments. Examples from peer reviewed publications as well as our own data will be presented.


Genvoy-ILM Webinar 2020


Overview
GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

An exclusive ionizable cationic lipid mix for preclinical development:

  • • Gene Therapy
  • • Cell Therapy
  • • Vaccine

 

With applications in oncology, rare diseases, and infectious diseases.

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

Endogenous Uptake

 

 

Screen Shot 2019-06-21 at 2.58.04 PM

Deliver mRNA for gene expression


A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.

 

 

Deliver siRNA for sustained gene knockdown


A single injection of GenVoy-ILM Luciferase mRNA-LNP was administered to mice via the tail vein at an RNA dose of 1 mg/mL. Luciferase expression was measured by 6-hours post-mRNA-LNP administration.

GenVoy-ILM FVII siRNA

Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

Nucleic Acid Lipid Nanoparticle

Both The Chemistry And The Process Determine The Outcome

 

LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



NanoAssemblr v Conventional T-tube
LNPs made with NanoAssemblr® Technology and containing siRNA against Factor VII results in more effective in vivo gene knockdown than those made with a T-junction. Lower bars indicate more effective knockdown of Factor VII measured in serum of mice treated intravenously with the indicated dose of siRNA.

Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

• 2 mL

• 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 

 

 

Screen Shot 2019-06-13 at 4.30.52 PM

 

 

Use Genvoy-ILM for: 

  • • Gene silencing 
  • • Gene expression 
  • • Gene editing 
  • • Gene modulation 

Use GenVoy-ILM to encapsulate and deliver RNA: 

  • • siRNA 
  • • miRNA 
  • • tRNA 
  • • gRNA 
  • • mRNA 

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

Resource Center

Poster

July 01, 2017

Plasmid-Lipid Nanoparticles – A Potent Tool for Manipulating Neuronal Genes In Vitro and In Vivo

Read More 阅读更多 PDF

Publication - Abstract

May 25, 2018

Multiple Myeloma

Microfluidic Production and Application of Lipid Nanoparticles for Nucleic Acid Transfection

A Thomas, SM Garg, RAG De Souza, E Ouellet, G Tharmarajah, D Reichert, M Ordobadi, S Ip, E C Ramsay

Read More 阅读更多

Publication - Abstract

March 19, 2018

Advanced Drug Delivery Reviews

Advances in Microfluidics for Lipid Nanoparticles and Extracellular Vesicles and Applications in Drug Delivery Systems

M. Maekia, N. Kimurab,Y. Satoc, H. Harashimac, M. Tokeshi

Read More 阅读更多

Publication - Abstract

June 03, 2017

Molecular Pharmaceutics

Formulation of Non-Ionic Surfactant Vesicles (NISV) Prepared by Microfluidics for Therapeutic Delivery of siRNA into Cancer Cells

Obeid MA, Elburi A, Young LC, Mullen AB, Tate RJ, Ferro VA

Read More 阅读更多

Video

August 10, 2017

SAM (Self Amplifying Message) for Rapid Response to Emerging Infectious Diseases - Derek O'Hagan

Read More 阅读更多

Publication - Summary

April 23, 2015

Cell

The Cellular Mechanisms of Neuronal Swelling Underlying Cytotoxic Edema

Rungta, Ravi L. et al

Read More 阅读更多
Resource Center 资源中心

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