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GenVoy-ILM™

Non-Viral LNP Delivery of RNA

Overview
GenVoy-ILM™ is an ionizable lipid mix that enables rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr™ platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

An exclusive ionizable cationic lipid is the key to:

  • • Excellent encapsulation
  • • Low toxicity
  • • High gene delivery potency

 

Start developing applications such as

  • • RNAi medicines
  • • Gene editing
  • • Protein/Enzyme replacement
  • • RNA vaccines

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

Endogenous Uptake

Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell. 

particle

Both the chemistry and the process determine the outcome

LNPs made with the NanoAssemblr™ platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



NA vs T-tube FVII KO
LNPs made with NanoAssemblr Technology and containing siRNA against Factor VII result in more effective in vivo gene knockdown than those made with a T-junction. Lower bars indicate more effective knockdown of Factor VII measured in serum of mice treated intravenously with the indicated dose of siRNA.

Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

• 2 mL

• 5 mL

GenVoy-ILM Vials

The Process is Part of The Outcome

NanoAssemblr technology is necessary to produce high quality LNPs. GenVoy-ILM is optimized for use with the NanoAssemblr Benchtop.

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

Resource Center

Video

November 30, 2016

"Nanoparticle Engineering by Microfluidics" - Ferdia Bates, BioNTech

Read More

Publication - Abstract

April 03, 2018

ACS Nano

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

J. Kulkarni , M. Darjuan, J. Mercer, S. Chen, R. van der Meel, J. Thewalt , Y. Tam, and P. Cullis

Read More

Publication - Summary

January 19, 2016

Proceedings of the National Academy of Sciences

Modular Degradable Dendrimers Enable Small RNAs to Extend Survival in an Aggressive Liver Cancer Model

Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ

Read More

Publication - Abstract

June 10, 2015

ACS Nano

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

Ramishetti S, Kedmi R, Goldsmith M, Leonard F, Sprague AG, Godin B, Gozin M, Cullis PR, Dykxhoorn DM, Peer D

Read More

Publication - Abstract

April 03, 2016

Nucleic Acids

A Glu-urea-Lys Ligand-Conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

Lee JB, Zhang K, Tam YY, Quick J, Tam YK, Lin PJ, Chen S, Liu Y, Nair JK, Zlatev I, Rajeev KG

Read More

Publication - Abstract

May 25, 2018

Multiple Myeloma

Microfluidic Production and Application of Lipid Nanoparticles for Nucleic Acid Transfection

A Thomas, SM Garg, RAG De Souza, E Ouellet,G Tharmarajah, D Reichert, M Ordobadi, S Ip, E C Ramsay

Read More
Resource Center

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