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GenVoy-ILM™

Non-Viral LNP Delivery of RNA

Overview
GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr™ platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

An exclusive ionizable cationic lipid is the key to:

  • • Excellent encapsulation
  • • Low toxicity
  • • High gene delivery potency

 

Start developing applications such as

  • • RNAi medicines
  • • Gene editing
  • • Protein/Enzyme replacement
  • • RNA vaccines

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

Endogenous Uptake

Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

Nucleic Acid Lipid Nanoparticle

Both the chemistry and the process determine the outcome.

 

LNPs made with the NanoAssemblr™ platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



NanoAssemblr v Conventional T-tube
LNPs made with NanoAssemblr® Technology and containing siRNA against Factor VII results in more effective in vivo gene knockdown than those made with a T-junction. Lower bars indicate more effective knockdown of Factor VII measured in serum of mice treated intravenously with the indicated dose of siRNA.

Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

• 2 mL

• 5 mL

GenVoy-ILM Vials

The Process is Part of The Outcome

NanoAssemblr® technology is necessary to produce high-quality LNPs. GenVoy-ILM is optimized for use with the NanoAssemblr® Benchtop.

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

Resource Center

Publication - Abstract

July 21, 2017

Methods in molecular biology

Preparation and Optimization of Lipid-Like Nanoparticles for mRNA Delivery

Li B, Dong Y

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Publication - Abstract

January 14, 2018

The Journal of Physical Chemistry

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

J. Viger-Gravel, A. Schantz, A. Pinon, A. Rossini , S. Schantz, and L. Emsley

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Publication - Abstract

February 15, 2018

Vaccine

Multi-Antigenic Human Cytomegalovirus mRNA Vaccines that Elicit Potent Humoral and Cell-Mediated Immunity

S. John, O. Yuzhakov, A. Woods, J. Deterling, K. Hassett, C. Shaw, G. Ciaramella

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Publication - Abstract

July 16, 2016

Molecular Therapy Nucleic Acids

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo.

Genc Basha, Mina Ordobadi, Wilder R Scott, Andrew Cottle, Yan Liu, Haitang Wang and Pieter R Cullis

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Webinar

April 26, 2016

Lipid Nanoparticle Delivery of siRNA to Unravel Chronic Pain

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Publication - Summary

December 03, 2013

Molecular Therapy—Nucleic Acids

Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

Rungta RL, Choi HB, Lin PJ, Ko RW, Ashby D, Nair J, Manoharan M, Cullis PR, MacVicar BA

Read More
Resource Center

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