company-header-background

GenVoy-ILM™

Non-Viral LNP Delivery of RNA

Overview
GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr™ platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

An exclusive ionizable cationic lipid is the key to:

  • • Excellent encapsulation
  • • Low toxicity
  • • High gene delivery potency

 

Start developing applications such as

  • • RNAi medicines
  • • Gene editing
  • • Protein/Enzyme replacement
  • • RNA vaccines

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

Endogenous Uptake

Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

Nucleic Acid Lipid Nanoparticle

Both the chemistry and the process determine the outcome.

 

LNPs made with the NanoAssemblr™ platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



NanoAssemblr v Conventional T-tube
LNPs made with NanoAssemblr® Technology and containing siRNA against Factor VII results in more effective in vivo gene knockdown than those made with a T-junction. Lower bars indicate more effective knockdown of Factor VII measured in serum of mice treated intravenously with the indicated dose of siRNA.

Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

• 2 mL

• 5 mL

GenVoy-ILM Vials

The Process is Part of The Outcome

NanoAssemblr® technology is necessary to produce high-quality LNPs. GenVoy-ILM is optimized for use with the NanoAssemblr® Benchtop.

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

Resource Center

Publication - Abstract

February 19, 2014

Drug Delivery and Translational Research

Lipid Nanoparticle Delivery Systems for siRNA-Based Therapeutics

Wan C, Allen TM, Cullis PR

Read More

Publication - Abstract

April 09, 2015

Journal of Liposome Research

Production of Limit Size Nanoliposomal Systems with Potential Utility as Ultra-Small Drug Delivery Agents

Zhigaltsev IV, Tam YK, Leung AK, Cullis PR

Read More

Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

Read More PDF

Publication - Abstract

December 03, 2015

Blood

Effective Treatment of Human CML By RNAi In Vivo in a Xenotransplantation Mouse Model

Nidhi Jyotsana et al.

Read More

Video

July 26, 2016

Liposomes: from Prototype to the Clinic | Norbert Maurer, Transferra Nanosciences

Read More

Publication - Summary

June 19, 2016

Neuromethods

Protocol for High-Content Screening for the Impact of Overexpressed MicroRNAs on Primary Motor Neurons

Yardeni, Tal and Hornstein, Eran

Read More
Resource Center

Stay Informed

Sign up today to automatically receive new Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.

MENU
X