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The
NanoAssemblr®

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Designed with the end in mind

Designed for the future

Designed to maximize time

NanoAssemblr Ignite
Polymeric Nanoparticle & Liposome
Precision NanoSystems introduces the next stage of enabling transformative medicines
The Ignite with NxGen Technology embodies everything that made the NanoAssemblr Platform the go-to for nanomedicine development for over 100 biopharma companies, while bringing the latest innovations developed for the cGMP system to the bench — saving time and money.
Designed with the End in Mind

Designed with End in Mind

Enabling researchers to create transformative medicines at the bench scale

Designed for the Future

Designed for Future

Enabling the creation of transformative medicines yet to be imagined

Designed to Maximize Time

Designed to Maximize Time

Enabling the creation of transformative medicines by accelerating data generation

Designed with the End in Mind.
Providing the capabilities to develop a robust, scalable process from the earliest stage
The manufacturing process on the GMP system can be modelled at any stage across the NanoAssemblr Platform. Ignite enables clinically relevant development processes at the bench.

DWEM - Unit Operation Workflow

 

  • Reduce the risk during transition from Research into Development
  • Reduce cost since downstream equipment is available at CMO facilities
  • Accelerate timelines to IND
Designed For the Future
As a team of scientists, engineers, and much more, we are working together to advance the technologies that lead the way in nanomedicine
NxGen microfluidics plus the third-inlet capability of the Ignite instrument provides an expandable system where new cartridge designs enable new applications

IgniteDilutionCartridge

The NanoAssemblr Ignite NxGen Dilution Cartridge enables automated in-line dilution of the nanoparticles as they emerge from the microfluidic mixer

Designed to Maximize Time
Time should be prioritized to designing and executing experiments, and analyzing data
Manufacturing processes should not be long or complex or increase risk of process error, batch failure, poor quality particles, and unreliable data Manufacturing process should not be limited to experienced specialists

Intuitive software allows frequently used manufacturing recipes to be stored minimizing batch-to-batch and user variability

Designed-for-time

 

System is ready in 3 simple steps with no priming or cleaning required. Nanomedicine formulations can be prepared in minutes allowing rapid optimization of particle properties


 

Polymeric Nanoparticle & Liposome
Summary of Features

NxGen logo

The Ignite brings the highly scalable power of NxGen microfluidic technology to the bench. The NxGen mixer uses precisely controlled time-invariant mixing to reproducibly generate optimal particles through a single mixer across scales. 

 

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Ignite_Reproducibility
outstanding reproducibility

Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.

Ignite_intutitive
intuitive workflow

Easy setup with touch screen interface, saved recipes and a single-use fluid path that eliminates priming and cleaning enables a streamlined workflow.

Ignite_controlled
controlled assembly

Tune particle size with precise control over fluid flow rates.

 
versatile

Formulate small molecules, peptides and, nucleic acids into lipid, polymer or hybrid nanoparticles, and more.

Ignite_Speedy

speedy and efficient

Formulation runs require less than a minute. Over 50 formulations can be completed in a day for rapid optimization.

Ignite_Scalable

 
scalable

Easily scale between 1mL and 20mL formulations on the Ignite. Optimized formulations can be predictably scaled to advanced preclinical and clinical scale with Blaze™ and GMP Systems with NxGen technology.

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

 

 

 

Advanced Technology for
Advanced Nanomedicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.

1

An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge

2

Under laminar flow, the two phases do not immediately mix

3

Microscopic features engineered into the channel reproducibly control the mixing of the two streams

4

Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
NanoAssemblr Technology
Ignite Video

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Ignite Cartridges

NanoAssemblr Ignite cartridges feature exclusive NxGen microfluidic technology that preserves time-invariant particle formation conditions and allows future scale up through a single mixer from ml / min to L /h.


Ignite_Cartridge_Illustration_600

Ignite cartridges are single-use. No priming or cleaning required for an efficient work flow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations. 


 

IgniteDilutionCartridge

NxGen Ignite cartridges are also available with automated in-line dilution of the nanoparticles to allow modelling of the processes that will be required for future GMP production.


 

Ignite Brochure
Ignite_brochure_thmThe NanoAssemblr® Ignite™ system is designed with the end in mind, designed for the future and designed to maxmize time.


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Resource Center

Publication - Abstract

June 03, 2019

Journal of Controlled Release

Formulation and manufacturing of lymphatic targeting liposomes using microfluidics

S. Khakde, C.B. Roces, A. Cameron, A Devit, Y. Perrie

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Publication - Abstract

February 27, 2019

Cell Chemical Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Y. Zhang, H. Tan, J.D. Daniels, F. Zandkarimi, H. Liu, L.M. Borwn, K. Uchida, O.A. O'Connor. B.R. Stockwell

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Publication - Summary

January 17, 2019

Nanomedicine: Nanotechnology, Biology and MEdicine

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo

S. Sieber, P. Grossen, P. Uhl, P. Detampel, W. Mier, D. Witzigmann, J. Huwyler

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Publication - Summary

January 06, 2019

Nanoscale

Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery

R Di Santo, L Digiacomo, S Palchetti, V Palmieri, G Perini, D Pozzi, M Papi, G Caracciolo

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Application Note

December 22, 2018

PLGA Microspheres Formulation and size-tuning using the NanoAssemblr® Benchtop

Read More 阅读更多 PDF

Publication - Abstract

December 18, 2018

Cell Reports

An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

L.A. VanBlarga, S, Himansu, B.M. Foreman, G.D. Ebel, T.C. Pierson, M.S.Diamond

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