Purple Corner Page Header
NanoAssemblr
GMP System

The Power to Commercialize

 

Configurable & modular system that is fit for purpose 

Continuous flow enables manufacturing scales 1L to 50L

Fluid path connects to downstream Tangential Flow Filtration systems to create a closed system

Fully disposable fluid path reduces risk & cost

Vendor-qualified to manufacture GMP microfluidic cartridges, de-risking most novel component of system

PNI’s QMS system compliant with cGMP requirements


GMP Specs
Scale-Up System
Polymeric Nanoparticle & Liposome

Flexible, Efficient & Reproducible 

Sirnaomics Case Study

GMP Quote
Screen Shot 2020-06-17 at 8.03.14 AM
Manufacture at Every Scale

GMP Value 1

Particle Size, Polydispersity and RNA Encapsulation Efficiency were Consistent as Production of Epo-encoded mRNA-LNP was Scaled using the NanoAssemblr® Platform
Manufacture at every scale
Scale-Up: Consistent Size
Scale-Up: Consistent Composition
Scale-Up: Consistent Activity
Scalability Through Parallelization

 

 

Nucleic Acid Lipid Nanoparticle
Liposome

 

Lipid Nanoparticles

 

Liposomes

 

 

 

Scale-Up Tech: Multiple Cartridges

 

 

Multiple microfluidic devices can perform the same operation in parallel to increase throughput. 




Emulsion
Polymeric Nanoparticle

 

Emulsions

 

Polymeric Nanoparticles

 

 

 

 

 

Microfluidic lipid nanoparticle (LNP) formulation. Nucleic acids in buffer (left) and LNP precursors in a solvent (right) are injected into the two inlets of a microfluidic cartridge, where they are mixed in a controlled fashion. LNPs of different sizes (far right) can be produced by varying the relative and total flow rates.


Scale-Up Technology: Formulation

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch

Resource Center

Publication - Abstract

July 01, 2020

Journal of Controlled Release

Delivery of Self-amplifying mRNA Vaccines by Cationic Lipid Nanoparticles: The Impact of Cationic Lipid Selection

G. Lou, G. Anderluzzi, S.T. Schmidt, S. Woods, S. Gallorini, M. Brazzoli, F. Giusti, I. Ferlenghi, R. Johnson, C.W. Rob...

Read More 阅读更多

Publication - Abstract

May 08, 2020

Vaccines

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

G. Anderluzzi, G. Lou, S. Gallorini, M. Brazzoli, R. Johnson, D.T. O'Hagan, B.C. Baudner and Y. Perrie

Read More 阅读更多

Publication - Abstract

April 02, 2020

Journal of Controlled Release

Design of a Novel Vaccine Nanotechnology-based Delivery System Comprising CpGODN-protein Conjugate Anchored to Liposomes

D. Chatzikleanthous, S.T. Schmidt, G. Buffi, I. Paciello, R. Cunliffe, F. Carboni, M.R. Romano, D.T. O'Hagan, U. D'Oro, ...

Read More 阅读更多

Publication - Abstract

December 31, 2019

Vaccines

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

C.B. Roces, M.T. Hussain, S.T. Schmidt, D. Christensen and Y. Perrie

Read More 阅读更多

Publication - Abstract

May 31, 2019

Vaccine

mRNA Vaccines Against H10N8 and H7N9 Influenza Viruses of Pandemic Potential Are Immunogenic and Well Tolerated in Healthy Adults ...

R.A. Feldman, R. Fuhr, I. Smolenov, A. Ribeiro, L. Panther, M. Watson, J.J. Senn, M. Smith, Ö. Almarsson, H.S. Pujar, M....

Read More 阅读更多

Publication - Summary

May 18, 2019

Annals of Hematology

Lipid Nanoparticle-mediated siRNA Delivery for Safe Targeting of Human CML In Vivo

N. Jyotsana, A. Sharma, A. Chaturvedi, M. Heuser et al.

Read More 阅读更多
Resource Center 资源中心
MENU
菜单
X
X