Next Generation Cancer Vaccine Summit Image
Next Generation Cancer Vaccine Summit


The Next Generation Cancer Vaccine Summit will take place at Wyndham Boston Beacon Hill in Boston August 16-18, 2022. Industry leaders will exchange ideas on adjuvant mechanisms, personalized vs off-the-shelf therapies and how best to overcome delivery challenges. 


Chat with Precision NanoSystems to learn how to identify, optimize, and scale-up potent LNP compositions using microfluidic platform technologies to rapidly develop cancer vaccines.  


Accelerating the Development of RNA-Based Medicines Using the Genomic Medicine Toolkit: A Case Study on Developing a COVID-19 mRNA-LNP Vaccine 


August 17, 2022 | 12:15 pm ET  


Jason Coleman Next Gen Cancer Dev SummitDr. Jason Coleman will explore how to accelerate development and manufacturing of novel lipid nanoparticle(LNP)-based therapeutics through scalable microfluidic technologies, off-the-shelf reagents, and a novel lipid library

Given the complexities and challenges for developing genomic cancer vaccines, it is critical to have a scalable and robust manufacturing platform for the development of non-viral delivery methods. 

This talk will share insights into a scalable manufacturing platform for RNA-LNPs and the use of this technology for the development of a high-potency self-amplifying (saRNA) LNP vaccine. We will also highlight key considerations for the development of a LNP vaccine drug product. 



Presentation Abstract


RNA can be designed to silence, express, and edit specific genes providing a flexible and powerful approach to treating diseases. While the development of RNA vaccines for COVID-19 is an extraordinary achievement, it has revealed that rapid development and scaling up – as well as access to necessary technologies – are required to keep up with emerging variants and to help usher in the new era RNA medicines in other therapeutic areas of unmet medical need. 
Precision NanoSystems has developed a Genomic Medicine Toolbox for the end-to-end development and manufacturing of RNA-lipid nanoparticles (RNA-LNPs). The toolbox comprises an RNA drug substance platform, a lipid nanoparticle drug delivery platform, and a microfluidic manufacturing platform. These tools are made accessible to scientists of different backgrounds by leveraging in-house expertise in RNA-LNP formulation, manufacturing, process and analytical development to engineer both our know-how and ease of use into them. In this presentation, we show data to demonstrate the versatility of the toolbox for the rapid development of vaccines, gene therapies and cell therapies. 

We are cited in over 500 publications, including the recently published articles focused on cancer vaccines: 


Additional Resources


LNP Build Up


Changing the Status Quo of Vaccine Production

Accelerating the Development web


Accelerating the Development and Scale-Up of mRNA Vaccines

YellowCrest (2)


NanoMedU: Learn More About Lipid Nanoparticle Vaccines

Read this article to learn how mRNA and LNP technologies, microfluidics, and distributed manufacturing will revamp vaccine production.

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Scale-up and downstream processing operations can impact the functionality and stability of mRNA-LNPs in vaccine development including COVID-19 vaccines.

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For 10 years, Precision NanoSystems has been lowering barriers to working successfully with RNA drug delivery technologies and furthering this goal, we're proud to provide NanoMedU: a focused classroom and hands-on learning program. 


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PNI’s NanoAssemblr™ Technology

The NxGen mixer enables the reproducible scale-up of mRNA-LNP and other complex nanomedicine formulations



NxGen Mixer for making RNA-LNPTest batches of up to 20 L/h produced with a single NxGen mixer

Particle characteristics (size and PDI) are consistent

Biological activity maintained

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