Nanomedicine Innovation Network
The Precision NanoSystems Global

Nanomedicine

Innovation

Network

“Shaping the Future”
November 2018
Harvard | Boston
Friday, October 26th 2018
Beth Israel Deaconess Medical Center (BIDMC) | Harvard Medical School
BIDMC Harvard
Speakers

Shell Ip, PhD

Precision NanoSystems Technical Specialist

 

Dr. Ip has a B.A.Sc. in Engineering Science and a Ph.D. in Chemistry from the University of Toronto. In his postdoctoral and doctoral research, he developed lipid coatings to render inorganic nanomaterials biocompatible and to tailor their surface properties for biosensing and biodiagnostics applications. He has severed several diverse roles at Precision NanoSystems for the last three years.

 

Title: Fundamentals of Nucleic Acid-Lipid Nanoparticle Formulation

 

Brief Description:

Nanoparticles offer a powerful, effective, safe and convenient means of delivering nucleic acids such as mRNA for therapeutic development or basic research that enables techniques such as RNAi, CRISPR and other methods of gene editing, as well as gene and cell therapies. This workshop will combine classroom and hands-on laboratory instruction to introduce key concepts and methods for getting started with making non-viral nanoparticle-based nucleic acid delivery systems. The classroom component will provide a molecular view of structure and function of nucleic acid lipid nanoparticles that will aid in understanding fundamental mechanisms underlying the encapsulation and delivery of nucleic acids via lipid nanoparticles. This understanding can guide the design and choice of nanoparticle components. The laboratory portion will provide hands-on experience with producing nucleic acid LNPs using the most advanced manufacturing system available – the NanoAssemblr® platform – at scales appropriate for early discovery through to late pre-clinical development, which paves the way to NanoAssemblr cGMP manufacturing that is available today.
Harvard Nanomedicine Innovation Network Schedule

 

 

 

Hands-On Experiments
The workshop will consist of speaker presentations, a catered lunch, and a wet lab demonstration with the complete NanoAssmblr® platform. Our goal is to is to provide an overview of the latest research and developments and highlight the remarkable work happening to foster learning and inspiration.



The Harvard location is one of five global Nanomedicine Innovation Network labs that will be conducting workshops and onsite demos.
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