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欲了解 Precision NanoSystems 如何加速从创意到临床应用的纳米药物研发过程,请联系我们的技术销售团队。
取得联系一种独有的可电离阳离子脂质是造就以下优点的关键要素:
适用于肿瘤学,罕见疾病和传染病。
脂质纳米颗粒模拟低密度脂蛋白,通过一条内源性途径摄取,旨在引发核酸在细胞质内的释放。
Deliver siRNA for sustained gene knockdown
A single injection of GenVoy-ILM Luciferase mRNA-LNP was administered to mice via the tail vein at an RNA dose of 1 mg/mL. Luciferase expression was measured by 6-hours post-mRNA-LNP administration.
LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.
At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.
These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.
Both The Chemistry And The Process Determine The Outcome
LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing.
GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.
• 2 mL
• 5 mL
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Publication - Abstract
May 25, 2018
Multiple Myeloma
Publication - Abstract
October 29, 2020
Journal of Medicinal Chemistry
Video
September 14, 2018
Video
July 26, 2016
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