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GenVoy-ILM™

非病毒脂质纳米颗粒 RNA 输送系统

概览
GenVoy-ILM™ 是一种可电离脂质混合物,使装载 RNA 的 脂质纳米颗粒 (LNP) 能够用  NanoAssemblr™ 平台方便快捷地制备。GenVoy-ILM 是开始使用脂质纳米颗粒时最简单的方式,也是最先进的非病毒核酸输送技术。

一种独有的可电离阳离子脂质是造就以下优点的关键要素:

  • • 包封效果出色
  • • 毒性低
  • • 基因输送效力高

 

适用于肿瘤学,罕见疾病和传染病。

脂质纳米颗粒模拟低密度脂蛋白,通过一条内源性途径摄取,旨在引发核酸在细胞质内的释放。

Endogenous Uptake

 

 

Screen Shot 2019-06-21 at 2.58.04 PM

Deliver siRNA for sustained gene knockdown


A single injection of GenVoy-ILM Luciferase mRNA-LNP was administered to mice via the tail vein at an RNA dose of 1 mg/mL. Luciferase expression was measured by 6-hours post-mRNA-LNP administration.

 

 

Deliver mRNA for gene expression


A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.
Asset 1

Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

Nucleic Acid Lipid Nanoparticle

Both The Chemistry And The Process Determine The Outcome

 

LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



NanoAssemblr v Conventional T-tube
LNPs made with NanoAssemblr® Technology and containing siRNA against Factor VII results in more effective in vivo gene knockdown than those made with a T-junction. Lower bars indicate more effective knockdown of Factor VII measured in serum of mice treated intravenously with the indicated dose of siRNA.

Product Information

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

• 2 mL

• 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 

 

 

Screen Shot 2019-06-13 at 4.30.52 PM

 

 

Use Genvoy-ILM for: 

  • • Gene silencing 
  • • Gene expression 
  • • Gene editing 
  • • Gene modulation 

Use GenVoy-ILM to encapsulate and deliver RNA: 

  • • siRNA 
  • • miRNA 
  • • tRNA 
  • • gRNA 
  • • mRNA 

开始

欲了解 Precision NanoSystems 如何加速从创意到临床应用的纳米药物研发过程,请联系我们的技术销售团队。

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资源中心

Publication - Summary

September 24, 2017

Nano Letters

Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA

Patel, A., Ashwanikumar, N., Robinson, E., DuRoss, A., Sun, C., Murphy-Benenato, K. E., Mihai, C., Almarsson, Ö., Sahay...

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Publication - Abstract

March 19, 2018

Advanced Drug Delivery Reviews

Advances in Microfluidics for Lipid Nanoparticles and Extracellular Vesicles and Applications in Drug Delivery Systems

M. Maekia, N. Kimurab,Y. Satoc, H. Harashimac, M. Tokeshi

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Video

August 16, 2017

Lipid Nanoparticles to Deliver Nucleic Acids in Neuroscience Research - Peter Johnson, PNI

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Publication - Abstract

January 15, 2016

Therapeutic Delivery

siRNA Delivery: Current Trends and Future Perspectives

Singh, Manu Smriti, and Dan Peer

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Video

July 28, 2016

NanoAssemblr® GMP Scale-Up System | Ray Lockard, Precision NanoSystems

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Publication - Summary

December 16, 2016

Angewandte Chemie International Edition

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ

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