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NanoAssemblr®
GMP System
Customized, Modular, Client-specific Scale-up System for cGMP
manufacture of Nanoparticles
- The GMP System can deliver manufacturing volumes in the range of 200 ml to tens of liters. The flexibility and scale in manufacturable volumes is achieved by “scaling out” made possible by arraying multiple microfluidic devices in parallel thus increases volume output without changing manufacturing conditions
- Fully disposable fluid path components to reduce risk and cost (re: cleaning validation)
- HPLC pumps designed for ultra-low pulsations in fluid flow. Specifically designed and custom made for the PNI’s system to facilitate access and easy replacement
- Components made of inert materials (Stainless Steel, PEEK, EPDM, COC) and microfluidic mixer material tested and cleared for extractables
- Designed to work with downstream processing systems (e.g. Tangential Flow Filtration) in a standard drug product manufacturing workflow
NanoAssemblr GMP System: Is a modular and configurable system, fit-for-purpose and phase appropriate, for the GMP manufacturing of nanomedicines.
Flexible, Efficient & Reproducible
Clinical Development
NanoAssemblr Technology: Ensures that the nanoparticle formation conditions are uniform, controlled and reproducible. Results in faster development times, easier scale up and higher production yields.
连续流动微流控平台专为
Nanoparticles manufactured on the GMP System are functionally similar to those produced with the NanoAssemblr® Benchtop and Blaze.
可通过并行运行扩大制备规模
脂质纳米颗粒
脂质体
Multiple microfluidic devices can perform the same operation in parallel to increase throughput.
乳剂
聚合物纳米颗粒
核酸脂质纳米颗粒 (LNP) 制备。缓冲液中的核酸（左）和溶剂中的脂质纳米颗粒前体（右）注入微流控试剂盒的两个入口，两者以可控的方式混合。通过改变相对流速和总流速，可以制备粒径大小不同的脂质纳米颗粒（最右）。
资源中心
Poster
September 01, 2022
Application Note
March 15, 2022
Publication - Abstract
July 01, 2020
Journal of Controlled Release
Publication - Abstract
May 08, 2020
Vaccines
Publication - Abstract
April 02, 2020
Journal of Controlled Release