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药物发现

 

研究疾病的生理学、细胞学和/或遗传学基础,以鉴定潜在治疗靶点。 

 

研发

鉴定出潜在靶点后,研究人员将会对成千上万的 API、辅料和/或制剂进行筛选,以寻找能够作用于该靶点的潜在候选物。

 

然而,经过早期试验,只有少数化合物表现出良好的应用前景,需要进一步研究。

 

我们已经步入了细胞疗法和基因疗法的时代,生物加工是一个关键要素。关键是能够对疾病产生分子水平的影响,而纳米药物技术为开创下一代基因和分子靶向治疗剂奠定了基础。


NanoAssemblr® 产品套件和制剂解决方案

NanoAssemblr Spark

 

NanoAssemblr® Spark™可制备以微升计量的纳米药物,供药物发现研究之用。

NanoAssemblr Benchtop

 

NanoAssemblr® Benchtop每次运行可制备 1 – 15 mL 纳米药物,供纳米药物研发计划之用。

Formulation Solution Experts

为了快速达到制剂概念验证阶段,PNI 制剂解决方案团队配备了拥有丰富制剂研发经验的合格科学家。

 

在每一步,我们的多学科专家将会与您合作,为未来的工作打下坚实的科学基础。


开始

欲了解 Precision NanoSystems 如何加速从创意到临床应用的纳米药物研发过程,请联系我们的技术销售团队。

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资源中心

Publication - Summary

May 18, 2019

Annals of Hematology

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo

N. Jyotsana, A. Sharma, A. Chaturvedi, et al.

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Publication - Summary

May 17, 2019

Science Immunology

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

N. Kose, J.M. Fox, G. Sapparapu, et al.

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Publication - Summary

April 04, 2019

The Journal of Neuroscience

PTCD1 is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease

D. Fleck, L. Phu, E. Verschueren, T. Hinkle, M. Reichelt, T. Bhangale, B. Haley, Y. Wang, R. Graham, D.S. Kirkpatrick, M...

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Publication - Summary

February 07, 2019

Nano Research

Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast can...

C. Zhang, X. Zhang, W. Zhao, C. Zeng, W. Li, B. Li, X. Luo, J. Li, J. Jiang, B. Deng, D.W. McComb, Y. Dong

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Application Note

January 16, 2019

mRNA Lipid Nanoparticles: Robust low-volume production for screening high-value nanoparticle materials

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Publication - Summary

September 24, 2018

Nucleic Acid Therapeutics

MicroRNAs Enable mRNA Therapeutics to Selectively Program Cancer Cells to Self-Destruct

R. Jain, JP. Frederick, EY. Huang, KE. Burke, DM. Mauger, EA. Andrianova, SJ. Farlow, S. Siddiqui, J. Pimentel, K. Cheun...

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