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Formulation
Solutions

Formulation Solutions leverages Precision NanoSystems’ research facilities, technical team and NanoAssemblr Platform to design flexible, custom nanomedicine formulation and nanoparticle manufacturing process development solutions.
Overview
Formulation Solutions projects span the entire nanoparticle formulation development continuum – from proof-of-concept nanoparticle formulations in early discovery, to advancing lead candidate development in scale-up, to optimization and technology transfer of nanoparticle manufacturing processes to CMO/manufacturing sites for cGMP production.

The Precision NanoSystems team uses proprietary NanoAssemblr microfluidic technology to develop optimized process parameters for manufacture of lipid-or polymer-based nanomedicines that meet target specifications.

Examples of Formulation Solutions projects and deliverables
• Nanoparticle formulation(s) suitable for proof-of-concept and pre-clinical testing

• Manufacturing support for NanoAssemblr Benchtop and Blaze users

• Tech transfer plan and manufacturing support to CMO/manufacturing site (for 8X NanoAssemblr Scale-Up System)

• Standard Operating Protocols for nanoparticle manufacture using the NanoAssemblr platform and products

• Standard Operating Protocols for downstream (ultrafiltration and diafiltration) processing of nanoparticles

• Analysis of nanoparticle physicochemical and biological properties

The Formulation Solutions’ team collaborates with customers to develop a well-defined project plan, with identified project deliverables, timelines and budget.

Talk to a Formulations Expert

Formulation Solutions projects span the entire nanoparticle formulation development continuum – from early discovery proof-of-concept nanoparticle formulations to CMO/manufacturing sites for cGMP production.

Talk to a Formulations Expert







Brochure
Formulation_Solutions_Brochure_Website-1For more information, please follow the link below for our Formulation Solutions brochure.

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Resource Center

Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

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Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr™ Platform

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Publication - Abstract

April 26, 2018

Small Methods

State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M.

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Publication - Abstract

February 27, 2018

Cell Reports

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

J. Finn, A. Smith, M. Patel, L. Shaw, M. Youniss, J. Heteren, T. Dirstine, C. Ciullo, R. Lescarbeau, J. Seitzer, R. Shah...

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Publication - Abstract

July 04, 2018

Nature communications

Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers

M Yu, L Xu, F Tian, Q Su, N Zheng, Y Yang

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Publication - Abstract

June 15, 2018

Molecular therapy

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

E Robinson, KD MacDonald, K Slaughter, M McKinney

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Resource Center