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Explore Novel Genetic
Medicine Formulations
Transformative medicines start with novel materials that can be costly or in limited supply. The Spark is ideal for screening novel genetic medicine formulations because it provides:
unmatched sample recovery
Advanced microfluidics allows microliter formulation volumes with near complete sample recovery.
intuitive operation
Simply pipette starting materials into wells, push a button, and pipette completed formulations out.
rapid production
The Spark formulation process requires less than 10 seconds, allowing hundreds of formulations to be made in hours.
Robust Process
Electronic control minimizes batch-to-batch and user variability.
workflow integration
The Spark system is designed for operation in a sterile biosafety hood, so formulations can be made on-demand, and applied to cells in culture.
scalable
NxGen microfluidic mixing technology allows formulations to be scaled across the NanoAssemblr Platform to accelerate future development.
See How Spark Works for Yourself
The Spark demo below will show you how the Spark can integrate into your workflow and accelerate your genetic medicine discovery.
Remarkably Fast and Easy to Use
Start operating the Spark with little to no training. Formulations are ready in seconds. Plus, they can be made on-demand in a sterile hood for immediate cell culture application.
pipette in
cap
insert
push start
pipette out
dilute
Accelerate Proof of Concept
Kick-start the validation of novel treatment modalities or formulations. Rapidly explore materials and parameters with minimal consumption of materials.
optimize formulations for size
screen targeting moieties
optimize mrna sequence and nucleotide modifications
Advanced Technology for
Advanced Genetic Medicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.
1
An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge2
Under laminar flow, the two phases do not immediately mix3
Microscopic features engineered into the channel reproducibly control the mixing of the two streams4
Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
Videos
Overview
NanoAssemblr Technology
Spark Demo
Accessories & Kits
spark cartridge
No cleaning or cleaning validation required: Cartridges are single-use and gamma irradiated for sterility. Available in packs of 20.
Spark formulation kits
Neuro9 kits contain everything you need to encapsulate siRNA into clinically validated lipid nanoparticle (LNP) delivery systems. Kits include a proprietary ionizable cationic lipid.
The NanoAssemblr Spark has an operating nanoparticle formulation volume of 25 – 250 μL. By ensuring yields nearing 100%, the Spark is ideal for target validation screening and nanoparticle
formulation development that involves scarce or expensive nucleic acid constructs and nanoparticle excipients.Download Brochure
Resource Center
Publication - Summary
April 04, 2019
The Journal of Neuroscience
Application Note
January 16, 2019
Publication - Abstract
November 01, 2018
Neuron
Poster
July 01, 2018
Publication - Abstract
May 25, 2018
Multiple Myeloma