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Ignite: Advancing Transformative Medicines
The Ignite with NxGen Technology embodies everything that makes the NanoAssemblr Platform the go-to for genetic medicine development
for over 100 biopharma companies, while bringing the latest innovations developed for the cGMP system to the bench — saving time and money.
Designed with the End in Mind
Enabling researchers to create genetic medicines at the bench scale
Designed for the Future
Enabling the creation of transformative medicines yet to be imagined
Designed to Maximize Time
Enabling the creation of genetic medicines by accelerating data generation
Ignite Empowers Genetic Medicine Advancement
Designed with the End in Mind.
Providing the capabilities to develop a robust, scalable process from the earliest stage
The manufacturing process on the GMP system can be modelled at any stage across the NanoAssemblr Platform with NxGen Technology. Ignite enables clinically relevant development processes at the bench.
Reduce the risk during transition from Research into Development
Reduce cost since downstream equipment is available at CMO facilities
Accelerate timelines to Investigational New Drug Applications
Designed for the Future
As a team of scientists, engineers, and much more, we are working together to advance the technologies that lead the way in genetic medicine
NxGen microfluidics plus the third-inlet capability of the Ignite instrument provides an expandable system where new cartridge designs enable new applications.
The NanoAssemblr Ignite NxGen Dilution Cartridge enables automated in-line dilution of the nanoparticles as they emerge from the microfluidic mixer.
Designed to Maximize Time
Time should be prioritized designing and executing experiments, and analyzing data
Manufacturing processes should not be long and complex or increase risk of process error, batch failure, poor quality particles or unreliable data. Process development should not be limited to experienced specialists.
Intuitive software allows frequently used manufacturing recipes to be stored minimizing batch-to-batch and user variability.
System is ready in 3 simple steps with no priming or cleaning required. Genetic medicine formulations can be prepared in minutes allowing rapid optimization of particle properties.
The Ignite brings the highly scalable power of NxGen microfluidic technology to the bench. The NxGen mixer uses precisely controlled time-invariant mixing to reproducibly generate optimal particles through a single mixer across scales.
outstanding reproducibility
Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.
intuitive workflow
Easy setup with touch screen interface, saved recipes and a single-use fluid path that eliminates priming and cleaning enables a streamlined workflow.
controlled assembly
Tune particle size with precise control over fluid flow rates.
versatile
Formulate small molecules, peptides and, nucleic acids into lipid, polymer or hybrid nanoparticles, and more.
speedy and efficient
Formulation runs require less than a minute. Over 50 formulations can be completed in a day for rapid optimization.
scalable
Easily scale between 1mL and 20mL formulations on the Ignite. Optimized formulations can be predictably scaled to advanced preclinical and clinical scale with Blaze™ and GMP Systems with NxGen technology.
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.
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An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge2
Under laminar flow, the two phases do not immediately mix3
Microscopic features engineered into the channel reproducibly control the mixing of the two streams4
Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
Ignite Video
Ignite Demo with GenVoy Training Kit
Ignite Informational Presentation
GenVoy Ignite Demo
Ignite Cartridges
NanoAssemblr Ignite cartridges feature exclusive NxGen microfluidic technology that preserves time-invariant particle formation conditions and allows future scale up through a single mixer from ml/min to L/h.
Ignite cartridges are single use. No priming or cleaning required for an efficient workflow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations.
Ignite cartridges with NxGen Technology are also available with automated in-line dilution of the nanoparticles to allow modelling of the processes that will be required for future GMP production.
The NanoAssemblr® Ignite™ system is designed with the end in mind, designed for the future and designed to maxmize time.Download Brochure
Resource Center
Publication - Abstract
December 16, 2020
pharmaceutics
Publication - Abstract
December 16, 2020
Advanced Therapeutics
Publication - Abstract
November 30, 2020
International Journal of Pharmaceutics
Publication - Abstract
November 19, 2020
Molecular Pharmaceutics
Publication - Abstract
November 18, 2020
Science Advances