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The
NanoAssemblr®

Ignite_logo_transp-01

Power to Advance

NanoAssemblr Ignite
Advance Novel Genetic Medicine Formulations

Genetic medicines have a wide design space that requires optimization to select a lead candidate. The Ignite is ideal for fine tuning process parameters and compositions for further scale up to the clinic.

 

Ignite_Reproducibility

 

Outstanding Reproducibility

 

Advanced microfluidics in an automated system removes batch-to-batch and user-to-user variability.

Ignite_Scalable

 

Scalable Technology

 

NxGen technology allows formulations to be rapidly scaled across the NanoAssemblr platform from 100 µL to 50 L.

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Simple Workflow

 

Easy setup with touchscreen interface, saved recipes and a single-use fluid path enables a streamlined workflow.

 

 

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Rapid Production


 Over 50 formulations can be completed in a day for rapid optimization with each run taking less than one minute.

 

Versatile

 

Lipid, polymer or hybrid nanoparticles carrying small molecules, peptides or nucleic acids (and more) can be formulated on the Ignite.

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Controlled Assembly

 

Particle sizes can be tuned with precise control over fluid flow rates.

Ignite Empowers Genetic Medicine Advancement

 

NanoMedU

Learn more about Early Pre-clinical Development Level 1: RNA Vaccines. A focused virtual classroom and hands-on training to kick-start RNA-LNP vaccine development

Learn More

 

 

Quick and Easy to Use

The Ignite is simple to use and can be operated with little to no training. Formulations can be completed in under a minute and made on demand to quickly optimize experimental parameters.

 

Ignite 2020

 

Ignite Process Illustrations-01

Insert Cartridge

Ignite Process Illustrations-02Load Pre-filled Syringes
Ignite Process Illustrations-03Choose a Recipe
Ignite Process Illustrations-04Load Collection Tubes
Ignite Process Illustrations-05Start Formulation
Ignite Process Illustrations-06Collect Sample

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact a Scientific Specialists.

Get in Touch
Scale Formulations with NxGen Technology Across the NanoAssemblr Platform
Using the same microfluidic geometry, formulations are scalable across the NanoAssemblr® platform greatly reducing process and formulation redevelopment when changing scales. Lipid nanoparticles containing nucleic acids maintain identical size and PDI when scaled across the platform.
NxGenMixer
Nanoparticle Size at Every Scale
EE At Every Scale

 

Particle Size, polydispersity and hematocrit expression were consistent as production of mRNA-LNP was scaled using the NanoAssemblr platform.

 

 

Optimize Genetic Medicine Formulations
Rationally optimize your formulations by controlling process and chemical parameters like flow rate, concentration and charge. Quick formulation times allow for an efficient systematic approach to finding lead genetic medicine candidates.
Polymer Nanoparticles on Ignite
Ignite Liposomes TFR
IgniteLiposomesFRR

Starting concentration, total flow rate and flow rate ratio parameters were varied, and 5 replicates were performed for each data point.

 

Enable Preclinical Experiments with Reproducible Formulations
Reproducibility across batches and users to enable critical preclinical experiments needed like small animal studies for genetic medicine development.
Reproducible PDI Ignite LNP
Encapsulation Efficiency Ignite
Mouse Study Ignite EPO data

Particle size and encapsulation efficiency were performed in 4 replicates. Protein expression (Epo) experiments performed to show in vivo efficacy of mRNA-LNP.

 

LaminarMixingTall
Advanced Technology for Advanced Nanomedicines

NxGen technology provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.

 

1

 

An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge

 

 

2

 

Under laminar flow, the two phases do not immediately mix

3

 

Microscopic features engineered into the channel reproducibly control the mixing of the two streams

 

 

4

 

Rapid, controlled, homogenous mixing produces homogeneous nanoparticles

Videos and Demonstrations

 

Ignite Demo with GenVoy Training Kit

 

Ignite Informational Presentation

 

GenVoy Ignite Demo

Accessories and Reagents

The Ignite has accessories and reagents available to expand the formulation capabilities and empower users to advance their genetic medicine.
Heating Insert

Heating Package

 

The heating package empowers users to heat and keep their formulations in syringes at temperature when operating the Ignite.

Genvoy ILM with Dye - 2mL

GenVoy-ILM

 

GenVoy-ILM is an off-the-shelf, research use only reagent that lowers the barriers the genetic medicine development that can be used on the Ignite.

 

 

Cartridges

NanoAssemblr Ignite cartridges feature exclusive NxGen microfluidic technology that allows future scale up through a single mixer from ml/min to L/h.


Single Use Cartridges

 

Ignite_Image-nd-front

 

No priming or cleaning required for an efficient workflow. Ignite cartridges are compatible with a wide range of solvents to make a diverse array of nanomedicine formulations. 

 

 

Automatic Inline Dilution 

 

Ignite Dilution Cartridge

 

Automated in-line dilution allows modelling of the processes that will be required for future GMP production of nanoparticles.

Brochure

The NanoAssemblr® Ignite™ system is designed with the end in mind, designed for the future and designed to maximize time.

 

 

 

 

 

 

Resource Center

Publication - Abstract

February 16, 2021

Communications Biology

A High-throughput Galectin-9 Imaging Assay for Quantifying Nanoparticle Uptake, Endosomal Escape and Functiona...

M.J. Munson, G. O'Driscoll, A.M. Silva, E. Lázaro-Ibáñez, A. Gallud, J.T. Wilson, A. Collé...

Read More 阅读更多

Publication - Abstract

December 16, 2020

pharmaceutics

Applying Microfluidics for the Production of the Cationic Liposome-Based Vaccine Adjuvant CAF09b

S.T. Schmidt, D. Christensen and Y. Perrie

Read More 阅读更多

Publication - Abstract

December 16, 2020

Advanced Therapeutics

Quantification of Cellular Drug Biodistribution Addresses Challenges in Evaluating In Vitro and In Vivo Encaps...

C.B. Rodell, P. Baldwin, B. Fernandez, R. Weissleder, S. Sridhar and J.M. Dubach

Read More 阅读更多

Publication - Abstract

November 30, 2020

International Journal of Pharmaceutics

Microfluidic Production of Protein Loaded Chimeric Stealth Liposomes

M.T. Hussain, M. Tiboni, Y. Perrie and L. Casettari

Read More 阅读更多

Publication - Abstract

November 19, 2020

Molecular Pharmaceutics

Recent Advances in Microfluidics for the Preparation of Drug and Gene Delivery Systems

M.A. Tomeh and X. Zhao

Read More 阅读更多

Publication - Abstract

November 18, 2020

Science Advances

Engineered Mutant α-ENaC Subunit mRNA Delivered by Lipid Nanoparticles Reduces Amiloride Currents in Cystic Fi...

A. Mukherjee, K.D. MacDonald, J. Kim, M.I. Henderson, Y. Eygeris and G. Sahay

Read More 阅读更多
Resource Center 资源中心