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NanoAssemblr
GMP System
Power to Commercialize
Scale-Up System
Features of the GMP System

Configurable & modular system that is fit for purpose 

Continuous flow enables manufacturing scales 1L to 50L

Fluid path connects to downstream Tangential Flow Filtration systems to create a closed system

Fully disposable fluid path reduces risk & cost 

Vendor-qualified to manufacture GMP microfluidic cartridges, de-risking most novel component of system

PNI’s QMS system compliant with cGMP requirements

 

Key Specifications of Standard GMP System

Formulation Volumes

1L to 50L

Flow Rate

20 - 200mL/min combined

Flow Rate Ratio (@Max. flow rate)

Up to 5:1

Hold Up Volume

100mL


Lipid Nanoparticle and Polymeric Nanoparticle

Flexible, Efficient

& Reproducible

Sirnaomics Case Study
Screen Shot 2020-06-17 at 8.03.14 AM GMP Quote

Manufacture at Every Scale
Reduce Cost GMP
Save Time GMP
Minimize Risk GMP

Particle Size, Polydispersity and RNA Encapsulation Efficiency were Consistent as Production of Epo-encoded mRNA-LNP was Scaled using the NanoAssemblr® Platform

 

Nanoparticle Size at Every Scale
EE At Every Scale

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch
Videos

 

Informational video of GMP System with Dr. Lloyd Jeffs

GMP System Demo with Dr. Lloyd Jeffs


Resource Center

Publication - Abstract

July 01, 2020

Journal of Controlled Release

Delivery of Self-amplifying mRNA Vaccines by Cationic Lipid Nanoparticles: The Impact of Cationic Lipid Select...

G. Lou, G. Anderluzzi, S.T. Schmidt, S. Woods, S. Gallorini, M. Brazzoli, F. Giusti, I. F...

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Publication - Abstract

May 08, 2020

Vaccines

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

G. Anderluzzi, G. Lou, S. Gallorini, M. Brazzoli, R. Johnson, D.T. O'Hagan, B.C. Baudner a...

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Publication - Abstract

April 02, 2020

Journal of Controlled Release

Design of a Novel Vaccine Nanotechnology-based Delivery System Comprising CpGODN-protein Conjugate Anchored to...

D. Chatzikleanthous, S.T. Schmidt, G. Buffi, I. Paciello, R. Cunliffe, F. Carboni, M.R. Ro...

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Publication - Abstract

December 31, 2019

Vaccines

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

C.B. Roces, M.T. Hussain, S.T. Schmidt, D. Christensen and Y. Perrie

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Publication - Abstract

May 31, 2019

Vaccine

mRNA Vaccines Against H10N8 and H7N9 Influenza Viruses of Pandemic Potential Are Immunogenic and Well Tolerate...

R.A. Feldman, R. Fuhr, I. Smolenov, A. Ribeiro, L. Panther, M. Watson, J.J. Senn, M. Smith...

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Publication - Summary

May 18, 2019

Annals of Hematology

Lipid Nanoparticle-mediated siRNA Delivery for Safe Targeting of Human CML In Vivo

N. Jyotsana, A. Sharma, A. Chaturvedi, M. Heuser et al.

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Resource Center 资源中心