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What is
Nanomedicine?

Revolutionizing Medicine
Following biologics, nanomedicines represent the next era in drug innovation. Current research has demonstrated improved performance, reduced side effects, and revolutionary new treatment strategies like personalized medicine.

Several nanomedicines are available on the market such as Doxil, Visudyne, and Vyxeos. The most clinically advanced RNA medicine—Patisiran—is enabled by lipid nanoparticle (LNP) technology.


What is Nanomedicine Size Chart


Commonly, nanomedicines consist of active pharmaceutical ingredients (API) such as small molecules or biologics packaged into nano-sized carriers made of excipients like lipids and polymers. Nanoparticles tend to be smaller than cells but larger than most biomolecules, so the nanomedicine can interact with the body differently than the API alone. The properties of nanomedicines can be designed to control when and where in the body the API is available.




What is Nanomedicine Active Ingredients

Applications of Nanomedicine
By packaging a variety of active pharmaceutical ingredients (API) into nanoparticles, drug innovators aim to:


Protect API
Protect the API
Control API
Control API Release
Alter API
Alter Biodistribution
Target Drug Delivery
Target drug delivery
to the site of disease
Soluble APIs
Enhance solubility
and bioavailability

Nanomedicines are at the Heart of Next-Generation Medicines
Nanomedicines currently being developed, allow treatment of otherwise "undruggable" targets to address unmet medical needs through revolutionary new strategies:

Nanomedicine: Future of Medicine

The Challenge



Using traditional methodologies, drug researchers face significant challenges in producing nanomedicines for R&D, clinical testing, and commercial manufacture.

 

Lipid Nanoparticle v Small Molecule

 

Nanoparticles consist of millions of molecules that need to come together and work in concert, and traditional production methods adapted from processes developed over decades for small molecule drugs do not adequately address the unique needs of nanomedicine production.



Traditional Methods:

Lack Consistency Nanomedicine: Quality Comparison

Are laborious/slow/low throughput Doxil process:
10 Steps
17 Process vessels
5 Days

Are difficult to scale Nanomedicine: Difficult to Scale

Require expertise/skill Nanomedicine: Requires Skill





Advanced Solutions for Advanced Medicines
Precision NanoSystems is enabling drug innovators to overcome unique challenges in creating transformative medicine by making purpose-designed manufacturing technology and unique nanomedicine expertise available to support all stages of nanomedicine development.
Liposome, LNP, Polymer NP, Emulsion

Resource Center

Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

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Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr® Platform

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Publication - Abstract

April 26, 2018

Small Methods

State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M.

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Publication - Abstract

February 27, 2018

Cell Reports

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

J. Finn, A. Smith, M. Patel, L. Shaw, M. Youniss, J. Heteren, T. Dirstine, C. Ciullo, R. Lescarbeau, J. Seitzer, R. Shah...

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Publication - Abstract

November 01, 2018

Neuron

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, B., Huntley, M. A., De Mazière, A., Meilandt, W. J., Wu, T., Srinivasan, K., . . . Sheng, M.

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Publication - Abstract

October 29, 2018

Nature Communications

Cell specific delivery of modified mRNA expressing therapeutic proteins to leukocytes

Nuphar Veiga, Meir Goldsmith, Yasmin Granot, Daniel Rosenblum, Niels Dammes, Ranit Kedmi, Srinivas Ramishetti & Dan Peer...

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Resource Center

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