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The
NanoAssemblr
Spark™
Freedom to Discover
With Instant Microliter
Nanomedicine Formulations
nanoassemblr-spark
double-microbes
Explore novel
nanomedicine
formulations
Revolutionary medicines start with novel materials that can be costly or in limited supply. The Spark is ideal for for screening novel formulations because it provides:
unmatched sample recovery

Advanced microfluidics allow microliter formulation volumes with near complete sample recovery.

 
intuitive operation

Simply pipette starting materials into wells, push a button, and pipette completed formulations out.

 
rapid production

The Spark formulation process requires less than 5 seconds, allowing hundreds of formulations to be made in hours.

 
Robust Process

Electronic control minimizes batch-to-batch and user variability.

workflow integration

The Spark system is designed for operation in a sterile biosafety hood, so formulations can be made on-demand, and appled to cells in culture.

 
scalable

Shared microfluidic mixing technology allow formulations to be scaled across the NanoAssemblr Platform to accelerate future development.

Remarkably Fast
and Easy to Use
Start operating the Spark with little to no training. Formulations are ready in seconds. And they can be made on-demand in a sterile hood for immediate cell culture application.
nanoassemblr-spark
first

pipette precursors

second

cap

third

insert

fourth

push start

fifth

pipette out

sixth

dilute

Accelerate Proof
of Concept
Kick-start the validation of novel treatment modalities or formulations. Rapidly explore materials and parameters with minimal consumption of materials.

optimize formulations for size

formulations-chart

screen targeting moieties
screen-targeting-graph
optimize mrna sequence and nucleotide modifications
optimize-mrna-graph

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

Get in Touch
Advanced Technology for
Advanced Nanomedicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly thats scalable from discovery to the clinic.

1

An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge

2

Under laminar flow, the two phases do not immediately mix

3

Microscopic features engineered into the channel reproducibly control the mixing of the two streams

4

Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
nanomedicine-technology
Videos

 

Overview

 

NanoAssemblr Technology

 

Spark Demo

Accessories & Kits
Spark Cartridge
spark cartridge

No cleaning or cleaning validation required: Cartridges are single-use and gamma irradiated for sterility. Available in packs of 100.

Neuro9 Kit
Spark formulation kits

Neuro9 kits contain everything you need to encapsulate siRNA into clinically validated lipid nanoparticle (LNP) delivery systems. Kits include a proprietary ionizable cationic lipid.

Spark Brochure
Spark Brochure_ThumbThe NanoAssemblr Spark has an operating nanoparticle formulation volume of 25 – 250 μL. By ensuring yields nearing 100%, the Spark is ideal for target validation screening and nanoparticle formulation development that involves scarce or expensive nucleic acid constructs and nanoparticle excipients.



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Resource Center

Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

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Publication - Abstract

May 25, 2018

Multiple Myeloma

Microfluidic Production and Application of Lipid Nanoparticles for Nucleic Acid Transfection

A Thomas, SM Garg, RAG De Souza, E Ouellet,G Tharmarajah, D Reichert, M Ordobadi, S Ip, E C Ramsay

Read More

Poster

December 04, 2017

Lipid Nanoparticles Deliver Nucleic Acids, Including CRISPR Components, in Primary Neurons

Read More PDF

Poster

July 02, 2017

Messenger RNA Lipid Nanoparticles – A potent tool for manipulating neuronal gene expression

Read More PDF

Poster

July 01, 2017

Plasmid-Lipid Nanoparticles – A Potent Tool for Manipulating Neuronal Genes In Vitro and In Vivo

Read More PDF

Video

March 03, 2017

The NanoAssemblr™ Spark™ | Workflow with NanoAssemblr™ Transfection Kits

Read More
Resource Center