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Lipid Nanoparticles (LNP) are the Most Clinically Advanced Non-Viral Delivery Technology 

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Overview
GenVoy-ILM™ is an ionizable lipid mix that enables the rapid and easy production of RNA-loaded lipid nanoparticles (LNPs) using the NanoAssemblr®Platform.  GenVoy-ILM is the simplest way to get started with LNPs - the most advanced non-viral technology for delivering nucleic acids.

An exclusive ionizable cationic lipid mix for preclinical development:

  • • Gene Therapy
  • • Cell Therapy
  • • Vaccine

 

With applications in oncology, rare diseases, and infectious diseases.

LNPs mimic low-density lipoproteins and are taken up through an endogenous pathway where they are designed to trigger the release of nucleic acids in the cytoplasm.

Endogenous Uptake
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Deliver mRNA for gene expression


A single injection of GenVoy-ILM Factor VII siRNA-LNP was administered to mice via the tail vein at the RNA doses indicated and plasma levels of Factor VII protein were measured up to 21 days post-administration.
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Lipid Nanoparticles

LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.

 

At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.

 

These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.

Nucleic Acid Lipid Nanoparticle

Both The Chemistry And The Process Determine The Outcome

 

LNPs made with the NanoAssemblr®Platform have a unique homogeneous structure that is more effective compared to other methods of manufacture such as T-tube mixing. 



Use Genvoy-ILM for: 

  • • Gene silencing 
  • • Gene expression 
  • • Gene editing 
  • • Gene modulation 

Use GenVoy-ILM to encapsulate and deliver RNA: 

  • • siRNA 
  • • miRNA 
  • • tRNA 
  • • gRNA 
  • • mRNA 
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Product Information


User Guide

GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.

 

• 2 mL

• 5 mL

GenVoy-ILM Vials

The Chemistry And The Process Affect The Outcome 

LNPs made with the NanoAssemblr platform exhibit a unique homogeneous core structure with exceptionally consistent size within and between batches, which has been shown to be more potent than particles made by other methods. 

 

 

 

 


Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Resource Center

Video

August 04, 2017

Ocular Delivery of mRNA - Patrick Baumhof, CureVac AG

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Publication - Abstract

February 29, 2020

Biomaterials

Nose-to-brain Delivery of Enveloped RNA - Cell Permeating Peptide Nanocomplexes for the Treatment of Neurodegenerative Diseases

E. Samaridou, H. Walgrave, E. Salta, D.M. Álvarez, V. Castro-López, M. Loza, and M.J. Alonso

Read More 阅读更多

Publication - Abstract

December 03, 2015

Blood

Effective Treatment of Human CML By RNAi In Vivo in a Xenotransplantation Mouse Model

N. Jyotsana, A. Sharma, A. Chaturvedi, C. Walsh, A. Thomas, M. Scherr, M. Heuser et al.

Read More 阅读更多

Publication - Abstract

November 30, 2019

Journal of Controlled Release

Lipid Nanoparticles of Type-A CpG D35 Suppress Tumor Growth by Changing Tumor Immune-microenvironment and Activate CD8 T Cells in ...

L. Munakata, Y. Tanimoto, A. Osa, J. Meng, Y. Haseda, Y. Naito, H. Machiyama, A. Kumanogoh, D. Omata, K. Maruyama, Y. Yo...

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Publication - Abstract

February 19, 2014

Drug Delivery and Translational Research

Lipid Nanoparticle Delivery Systems for siRNA-Based Therapeutics

C. Wan, T.M. Allen and P.R. Cullis

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Publication - Abstract

June 10, 2015

ACS Nano

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

S. Ramishetti, R. Kedmi, M. Goldsmith, F. Leonard, A.G. Sprague, B. Godin, M. Gozin, P.R. Cullis, D.M. Dykxhoorn and D. ...

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