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Advance Preclinical
Nanomedicine Programs
NanoAssemblr Blaze
Polymeric Nanoparticle & Liposome

Introducing NxGen Blaze and

NxGen Blaze+



Preclinical testing made easy
Prior to clinical studies, safety and efficacy must be tested in multiple species. Use the NanoAssemblr Blaze to achieve:


Speedy And efficient

Efficient formulation for large preclinical studies.

Easy Scale-up

Easy scale-up of formulations developed on the NanoAssemblr® Ignite.


High capacity

Greater formulation capacity with the simplicity and efficiency of the NanoAssemblr® Ignite.


of inline dilution

Validation of Inline Dilution up to 5L.

high range
of formulation

Formulation of 10 mL to 1L batches.

Scalable upstream
and downstream

Scale-up development of upstream and downstream processes.

Case Study
Advanced Pre-clinical Studies Require Scalable Production Enabled by NanoAssemblr Technology
In a 2017 study, researchers from MD Anderson and Arcturus Therapeutics describe an immuno-oncology treatment for intracerebral glioma based on microRNA delivered by lipid nanoparticles. Their study involved escalating dose and repeat dose studies in a large model.
Based on stated doses, it is estimated that over 100 mL of formulation would be required per replicate to carry out this experiment. Their study involved 6 replicates. The NanoAssemblr® Blaze with a capacity of up to 1000 mL is ideal for reproducible formulation for advanced preclinical studies.
NanoAssemblr Blaze Case Study
Versatile Scalability
Using the same microfluidic geometry, formulations are scalable across the NanoAssemblr® platform. This greatly reduces process and formulation redevelopment when changing scales, compared to conventional batch-based methodologies. Liposomes, polymers and nucleic acid LNPs maintain identical size and PDI when scaled across the platform.
NanoAssemblr Cartridge Comparison
NanoAssemblr Liposome Scalability
NanoAssemblr Polymer Scalability
NanoAssemblr LNP Scalability

Get Started

To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Advanced Technology for Advanced Nanomedicines
Non-turbulent microfluidic mixing provides unparalleled control over nanoparticle assembly that is scalable from discovery to the clinic.


An aqueous phase and a miscible solvent containing dissolved nanoparticle precursors are injected into each inlet of the NanoAssemblr cartridge


Under laminar flow, the two phases do not immediately mix


Microscopic features engineered into the channel reproducibly control the mixing of the two streams


Rapid, controlled, homogenous mixing produces homogeneous nanoparticles
NanoAssemblr® Technology




NanoAssemblr Technology


Blaze Demo

Blaze Cartridges
NanoAssemblr® Blaze™ cartridges share the same microfluidic architecture as the Ignite and GMP Systems so parameters can be directly transferred between instruments to accommodate different scales of production. Cartridges are single-use and available with and without in-line dilution. Blaze cartridges are sold individually.
NanoAssemblr Blaze Cartridge
Blaze Brochure
NanoAssemblr Blaze BrochureThe NanoAssemblr® Blaze allows rapid scaling of nanoparticle formulations for late pre-clinical development. The system can manufacture between 10 mL and 1 L which allows researchers to use the Blaze for preclinical toxicology testing, and for early Chemistry, Manufacturing and Controls (CMC) studies.

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Resource Center

Publication - Abstract

November 29, 2018

International Journal of Pharmaceutics

Rapid and Scale-independent Microfluidic Manufacture of Liposomes Entrapping Protein Incorporating In-line Purification and At-lin...

N. Forbes, MT. Hussain, ML. Briuglia, DY. Edwards, JH. terHorst, N. Szita, Y. Perrie

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Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr® Platform

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June 11, 2018

Rapid development and seamless scale-up of genetic nanomedicines

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April 01, 2018

A Scalable Microfluidics Platform for the Development of Nanoparticles

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March 06, 2018

Manufacture of Verteporfin Loaded Liposomes using a Scalable Microfluidic Platform

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Application Note

January 02, 2018

Seamless scale up of siRNA LNP formulations using the NanoAssemblr® platform

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