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Deliver siRNA for sustained gene knockdown
A single injection of GenVoy-ILM Luciferase mRNA-LNP was administered to mice via the tail vein at an RNA dose of 1 mg/mL. Luciferase expression was measured by 6-hours post-mRNA-LNP administration.
LNPs contain a pH-sensitive ionizable cationic lipid that attract anionic nucleic acids to form the core of self-assembling nanoparticle to ensure high encapsulation.
At physiological pH, LNPs are neutral, eliminating a mechanism of toxicity seen with permanently cationic molecules.
These same pH-sensitive lipids are responsible for responding to the acidic environment of the endosome and triggering the disruption of the endosome and release of the nucleic acid into the cell.
GenVoy-ILM is a pre-blended lipid mix in ethanol and is available in two formats with or without added dye for visualization.
• 2 mL
• 5 mL
April 24, 2019
October 20, 2016
Publication - Abstract
December 06, 2017
November 30, 2016
Publication - Summary
May 17, 2019
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