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药物发现

 

研究疾病的生理学、细胞学和/或遗传学基础,以鉴定潜在治疗靶点。 

 

研发

鉴定出潜在靶点后,研究人员将会对成千上万的 API、辅料和/或制剂进行筛选,以寻找能够作用于该靶点的潜在候选物。

 

然而,经过早期试验,只有少数化合物表现出良好的应用前景,需要进一步研究。

 

我们已经步入了细胞疗法和基因疗法的时代,生物加工是一个关键要素。关键是能够对疾病产生分子水平的影响,而纳米药物技术为开创下一代基因和分子靶向治疗剂奠定了基础。


NanoAssemblr® 产品套件和制剂解决方案

NanoAssemblr Spark

 

NanoAssemblr® Spark™可制备以微升计量的纳米药物,供药物发现研究之用。

NanoAssemblr Benchtop

 

NanoAssemblr® Benchtop每次运行可制备 1 – 15 mL 纳米药物,供纳米药物研发计划之用。

Formulation Solution Experts

为了快速达到制剂概念验证阶段,PNI 制剂解决方案团队配备了拥有丰富制剂研发经验的合格科学家。

 

在每一步,我们的多学科专家将会与您合作,为未来的工作打下坚实的科学基础。


开始

欲了解 Precision NanoSystems 如何加速从创意到临床应用的纳米药物研发过程,请联系我们的技术销售团队。

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资源中心

Publication - Abstract

May 08, 2020

Vaccines

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

G. Anderluzzi, G. Lou, S. Gallorini, M. Brazzoli, R. Johnson, D.T. O'Hagan, B.C. Baudner and Y. Perrie

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Publication - Abstract

April 02, 2020

Journal of Controlled Release

Design of a Novel Vaccine Nanotechnology-based Delivery System Comprising CpGODN-protein Conjugate Anchored to Liposomes

D. Chatzikleanthous, S.T. Schmidt, G. Buffi, I. Paciello, R. Cunliffe, F. Carboni, M.R. Romano, D.T. O'Hagan, U. D'Oro, ...

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Publication - Abstract

December 31, 2019

Vaccines

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

C.B. Roces, M.T. Hussain, S.T. Schmidt, D. Christensen and Y. Perrie

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Publication - Abstract

May 31, 2019

Vaccine

mRNA Vaccines Against H10N8 and H7N9 Influenza Viruses of Pandemic Potential Are Immunogenic and Well Tolerated in Healthy Adults ...

R.A. Feldman, R. Fuhr, I. Smolenov, A. Ribeiro, L. Panther, M. Watson, J.J. Senn, M. Smith, Ö. Almarsson, H.S. Pujar, M....

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Publication - Summary

May 18, 2019

Annals of Hematology

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo

N. Jyotsana, A. Sharma, A. Chaturvedi, et al.

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Publication - Summary

May 17, 2019

Science Immunology

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection

N. Kose, J.M. Fox, G. Sapparapu, et al.

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