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Polymeric Nanoparticles
Naked-NanoparticlePolymer-based nanoparticles can improve the efficacy, solubility, toxicity, bioavailability and pharmacokinetic profile of a drug molecule. Numerous applications are being developed, including:
• Biodistribution of chemotherapeutic agents in tumours to reduce off-target toxicity and widen the therapeutic window
• Encapsulation and delivery of biomolecules for genetic medicine, gene-editing, and immunotherapy
• Encapsulation and co-delivery of multiple APIs and/or image contrast agents for combination drug therapy or theranostics

Overcoming Key Challenges in Advancing Polymer Nanoparticle Formulations


Challenges with Conventional Production Solutions with the NanoAssemblr Platform
The formulation process has significant batch-to-batch variabilityorangeRightArrowReproducible polymer nanoparticle manufacturing process
Maintaining precise control over the particle size is difficultorangeRightArrowControl particle size through instrument parameters
Loading the nanoparticles is inefficientorangeRightArrowHigh drug loading efficiency in a one-step formulation process
Production is time consuming and labor-intensiveorangeRightArrowEnabling rapid, effortless polymer nanoparticle production and optimization
The manufacturing process is difficult to scale-uporangeRightArrowA seamless path to scaling up production

Key Benefits


Highly reproducible polymer nanoparticle manufacturing


Polymer ReproducibilityPLGA nanoparticles smaller than 100nm in size, produced in three separate batches by three independent operators, demonstrating interoperator and batch-to-batch consistency.


Control particle size through convenient instrument parameters

PEG-PLGA polymr size control TFR
The size of PEG-PLGA block-copolymer micelles were tuned using the Total Flow Rate (TFR). Dial in parameters to achieve a specific size with the same polymer.


High drug loading efficiency in a one-step formulation process

Polymer Drug Encap EE
PLGA nanoparticles formed in the presence of model drug Coumarin6 exhibit high encapsulation efficiency.


A seamless path to scaling up production

PLGA polymer scalability
Formulation parameters optimized on the Benchtop (up to 15 mL) were transferred unchanged to the Blaze (up to 1000 mL) and the same size and PDI were achieved for PLGA-NPs. Samples can also be concentrated as desired using centrifugal filtration and tangential flow filtration.

How It Works

cartridge-schematic




Polymers in a solvent are mixed with an aqueous phase in the NanoAssemblr microfluidic cartridge where rapid, homogeneous mixing ensures particles are formed under consistent conditions. Computer controlled independent injection of both liquids allows mixing speed and mixing ratio to be easily dialled-in to systematically optimize particle formation parameters.

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To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.

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Polymer Nanoparticle Resources

Publication - Abstract

July 04, 2018

Nature communications

Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers

M Yu, L Xu, F Tian, Q Su, N Zheng, Y Yang

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Publication - Abstract

June 01, 2018

Biological and Pharmaceutical Bulletin

The Use of an Efficient Microfluidic Mixing System for Generating Stabilized Polymeric Nanoparticles for Controlled Drug Release

Y Morikawa, T Tagami, A Hoshikawa, T Ozeki

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Publication - Abstract

May 07, 2018

Bioconjugate Chemistry

Nanoparticle Formulation Derived from Carboxymethyl Cellulose, Polyethylene Glycol, and Cabazitaxel for Chemotherapy Delivery to t...

J Bteich, MJ Ernsting, MZ Mohammed, T. Kiyota†, T. D. McKee§, M. Trikha∥, H. B. Lowman, and K. K. Sokoll

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Publication - Abstract

April 05, 2018

Advanced Drug Delivery Reviews

Transforming Nanomedicine Manufacturing toward Quality by Design and Microfluidics

Colombo, S., Beck-Broichsitter, M., Bøtker, J. P., Malmsten, M., Rantanen, J., & Bohr, A

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Publication - Abstract

February 27, 2018

Langmuir

Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation- Responsive Polyester-Based Nanoparticulates with Controlled Sizes for D...

S. H. Hong, T. Patel, S. Ip, S. Garg, and J. K. Oh

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Publication - Abstract

February 12, 2018

Journal of Nanobiotechnology

Optimization and Scale up of Microfluidic Nanolipomer Production Method for Preclinical and Potential Clinical Trials

A. Gdowski, K. Johnson, S. Shah, I. Gryczynski, J. Vishwanatha and A. Ranjan

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