Scientist Holding Small Formulation
Adaptable Nanoparticle Research and Development
Using NanoAssmemblr® technology, develop a broad range of nanoparticle formulations, varying in size, payload and excipient characteristics. Find new designs for difficult-to-deliver drugs and hard-to-treat targets.


Particle Type
Active Ingredients
Nucleic Acid
Peptides and Proteins
Small Molecules
Imaging Contrast Agents
Carrier Materials
  • Ionizable lipids
  • Phospholipids
  • Cholesterol
  • PEG-Lipids
  • Phospholipids
  • Cholesterol
  • PEG-Lipids
  • Poly-lactides (ex: PLGA)
  • Block copolymers (ex: PEG-b-PLGA)
  • Polysaccharides (ex: chitosan, cellulose)
Emulsions
  • Triolein/POPC
  • Oil/Surfactant
Organic / Inorganic NPs
  • Lipids
  • Noble metal NPs
  • Rare Earth Metals
  • III-V semiconductors


Precision NanoSystems technology has enabled the development of a broad range of nanoparticle formulations, varying in size (20nm to 200nm), payload (e.g. nucleic acids, hydrophobic drugs) and excipient characteristics (e.g. charge and pH tuning). With the ability to iterate and tune particle characteristics faster than before, researchers are finding new designs and opening up possibilities for targets and drugs that previously would have been difficult or taken too long to develop.

In addition to the above, other particle types have also been developed on the NanoAssemblr® platform.

Particle TypeCompositionRelated Resources
NiosomesNon-ionic surfactant-based VesicleView Paper
Nano-lipomerHybrid particles made of lipids and polymers View Paper
Dendrimer NanoparticleModular biodegradable dendrimer carrying miRNAView Paper

Related Publications

Publication - Abstract

April 26, 2018

Small Methods

State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery

Evers, M. J. W., Kulkarni, J. A., van der Meel, R., Cullis, P. R., Vader, P., & Schiffelers, R. M.

Read More

Publication - Abstract

February 27, 2018

Cell Reports

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

J. Finn, A. Smith, M. Patel, L. Shaw, M. Youniss, J. Heteren, T. Dirstine, C. Ciullo, R. Lescarbeau, J. Seitzer, R. Shah...

Read More

Publication - Abstract

November 01, 2018

Neuron

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, B., Huntley, M. A., De Mazière, A., Meilandt, W. J., Wu, T., Srinivasan, K., . . . Sheng, M.

Read More
Resource Center

Related Resources

Application Note

July 01, 2018

Seamless scale up of liposomal verteporfin formulations using the NanoAssemblr® Platform

Read More PDF

Poster

July 01, 2018

Robust low-volume production of nanoparticles for genetic manipulation of cells

Read More PDF

Video

September 14, 2018

From Concept to Reality: Development of Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics - Martin Maier, Alnylam

Read More
Resource Center

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